Now showing items 21-30 of 47
Development of a Chemoproteomic Approach to Study Kinase-Substrate Interactions and the Discovery of CDK4 as a 4E-BP1 Kinase
(2019)
An instrumental aspect of cancer progression is the acquired deregulation of the cellular processes that regulate growth and proliferation. Most of these processes are, at some level, controlled by a kinase-catalyzed change ...
Examination of Aggregation Prone Proteins and their Higher Order Interactions by Ion Mobility-Mass Spectrometry.
(2015)
Amyloid forming peptides and proteins present an extreme challenge for modern analytical measurement techniques. When natively-folded biomolecules partition into misfolded forms, they produce a myriad of inherently unstable ...
Biological Applications of Surfaces with Extreme Wettabilities
(2019)
Surfaces with extreme wettabilities have become an increasingly popular topic due to their wide range of applications – from simply keeping dirt off clothing to oil-water separation in the event of an oil spill. In particular, ...
Combining Active Site and Allosteric Inhibitors to Study Protein Tyrosine Kinases
(2016)
Kinases play a crucial role in a variety of cell signaling pathways that control processes such as: growth, motility, and angiogenesis. Not surprisingly, dysregulation of proper kinase signaling often leads to cancer. Since ...
Advances in in Vivo Neurochemical Monitoring Using Microdialysis with Liquid Chromatography-Mass Spectrometry
(2020)
Improving our understanding of the central nervous system necessitates developing techniques capable of making neurochemical measurements in the complex extracellular environment of the brain within living animal models. ...
Microfluidic Technologies for Bioanalytical Chemistry: Advancing Epigenetic Profiling via Chromatin Immunoprecipitation in Droplets
(2019)
Beyond the linear sequence of the genome, the epigenome dynamically controls chromatin remodeling and transcriptional poise without inducing changes in DNA sequence. These epigenetic mechanisms, particularly modifications ...
Synthesis and Biochemical Evaluation of Multifunctional Acetylcholinesterase Inhibitor Hybrids for Treatment of Alzheimer's Disease.
(2014)
Alzheimer’s disease (AD) places a significant and dramatically increasing burden on society. While pathological hallmarks of this neurodegenerative disorder are known, the exact cause remains unclear. Acetylcholinesterase ...
Directed Evolution of Stabilized Peptides with Bacterial Display
(2020)
Interactions between proteins govern cellular and the body’s states, including aberrant interactions found in diseases such as in cancers and infections. Small molecule drugs are not ideal in targeting these interactions ...
Peptide and Nonpeptide Approaches to Target Protein-protein Interactions for the Treatment of Cancer.
(2015)
Protein-protein interactions (PPIs) are macromolecular contacts critical in physiological processes and they play a role in both normal cellular processes and disease pathogenesis. Targeting PPIs represents a new but poorly ...
High Throughput Experimentation Facilitated Development of Amine-Acid Cross Coupling Reactions
(2023)
High throughput experimentation (HTE) is an important technique which can expedite the hit-to-lead process in drug discovery. The first chapter of this thesis reviews reported applications using HTE in medicinal chemistry ...