Upper Gastrointestinal pH in Seventy-Nine Healthy, Elderly, North American Men and Women
dc.contributor.author | Dressman, Jennifer B. | en_US |
dc.contributor.author | Jarvenpaa, Kathleen M. | en_US |
dc.contributor.author | Russell, Tanya L. | en_US |
dc.contributor.author | Barnett, Jeffrey L. | en_US |
dc.contributor.author | Berardi, Rosemary R. | en_US |
dc.contributor.author | Dermentzoglou, Lambros C. | en_US |
dc.contributor.author | Schmaltz, Stephen P. | en_US |
dc.date.accessioned | 2006-09-08T19:14:42Z | |
dc.date.available | 2006-09-08T19:14:42Z | |
dc.date.issued | 1993-02 | en_US |
dc.identifier.citation | Russell, Tanya L.; Berardi, Rosemary R.; Barnett, Jeffrey L.; Dermentzoglou, Lambros C.; Jarvenpaa, Kathleen M.; Schmaltz, Stephen P.; Dressman, Jennifer B.; (1993). "Upper Gastrointestinal pH in Seventy-Nine Healthy, Elderly, North American Men and Women." Pharmaceutical Research 10(2): 187-196. <http://hdl.handle.net/2027.42/41426> | en_US |
dc.identifier.issn | 0724-8741 | en_US |
dc.identifier.issn | 1573-904X | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/41426 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8456064&dopt=citation | en_US |
dc.description.abstract | Gastric and duodenal pH levels were measured in 79 healthy, elderly men and women (mean ± SD = 71 ± 5 years) under both fasted and fed conditions using the Heidelberg capsule technique. The pH was recorded for 1 hr in the fasted state, a standard liquid and solid meal of 1000 cal was given over 30 min, then the pH was measured for 4 hr postprandially. Results are given as medians and interquartile ranges: fasted gastric pH, 1.3 (1.1–1.6); gastric pH during the meal, 4.9 (3.9–5.5); fasted duodenal pH, 6.5 (6.2–6.7); and duodenal pH during the meal, 6.5 (6.4–6.7). Although fasted gastric pH, fasted duodenal pH, and duodenal pH during the meal differ statistically from those observed in young subjects, the differences are not expected to be clinically significant in terms of drug absorption for the majority of elderly subjects. Following a meal, gastric pH decreased from a peak pH of 6.2 (5.8–6.7) to pH 2.0 within 4 hr in most subjects. This rate of return was considerably slower than in young, healthy subjects. Nine subjects (11%) had a median fasted gastric pH >5.0, and in five of these subjects the median pH remained >5.0 postprandially. In this group, drugs and dosage forms which require an acidic environment for dissolution or release may be poorly assimilated. | en_US |
dc.format.extent | 1599448 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media | en_US |
dc.subject.other | Biomedical Engineering | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.subject.other | Duodenal PH | en_US |
dc.subject.other | Elderly | en_US |
dc.subject.other | Food Effects | en_US |
dc.subject.other | Fed-state PH | en_US |
dc.subject.other | Fasted-state PH | en_US |
dc.subject.other | Heidelberg Radiotelemetry Capsule | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Pharmacy | en_US |
dc.subject.other | Gender Effects | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Medical Law | en_US |
dc.subject.other | Gastric PH | en_US |
dc.title | Upper Gastrointestinal pH in Seventy-Nine Healthy, Elderly, North American Men and Women | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Clinical Research Center, The University of Michigan Hospital, Ann Arbor, Michigan, 48109; JCAHO, 204 Bay Colony, Naperville, Illinois, 60565 | en_US |
dc.contributor.affiliationum | College of Pharmacy, The University of Michigan, Ann Arbor, Michigan, 48109 | en_US |
dc.contributor.affiliationum | School of Medicine, The University of Michigan Hospital, Ann Arbor, Michigan, 48109 | en_US |
dc.contributor.affiliationum | College of Pharmacy, The University of Michigan, Ann Arbor, Michigan, 48109 | en_US |
dc.contributor.affiliationum | College of Pharmacy, The University of Michigan, Ann Arbor, Michigan, 48109; Marion Merrell Dow Inc., Marion Park Drive, P.O. Box 9627, Kansas City, Missouri, 64134 | en_US |
dc.contributor.affiliationum | Clinical Research Center, The University of Michigan Hospital, Ann Arbor, Michigan, 48109 | en_US |
dc.contributor.affiliationum | College of Pharmacy, The University of Michigan, Ann Arbor, Michigan, 48109; Elpen S.A. Pharmaceutical Industries, 190 09, Pikermi, Greece | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 8456064 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/41426/1/11095_2004_Article_304755.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1023/A:1018970323716 | en_US |
dc.identifier.source | Pharmaceutical Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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