The Role of Rheological Properties in Mucociliary Transport by Frog Palate Ciliated Model
dc.contributor.author | Yu, Danny M. | en_US |
dc.contributor.author | Fleisher, David | en_US |
dc.contributor.author | Weiner, Norman D. | en_US |
dc.contributor.author | Goldberg, Arthur H. | en_US |
dc.contributor.author | Amidon, Gordon L. | en_US |
dc.date.accessioned | 2006-09-08T19:15:29Z | |
dc.date.available | 2006-09-08T19:15:29Z | |
dc.date.issued | 1994-12 | en_US |
dc.identifier.citation | Yu, Danny M.; Amidon, Gordon L.; Weiner, Norman D.; Fleisher, David; Goldberg, Arthur H.; (1994). "The Role of Rheological Properties in Mucociliary Transport by Frog Palate Ciliated Model." Pharmaceutical Research 11(12): 1785-1791. <http://hdl.handle.net/2027.42/41438> | en_US |
dc.identifier.issn | 1573-904X | en_US |
dc.identifier.issn | 0724-8741 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/41438 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7899245&dopt=citation | en_US |
dc.description.abstract | The effect of viscoelastic properties on mucociliary transport rate was investigated using the frog palate ciliated model. Mucociliary transportability of several hydrophilic polymeric gels with widely different viscoelastic characteristics were tested on the frog palate mucociliary model. An apparent negative relationship is observed between the relative transport rate (TR) and storage (G 1 ) or loss (G 2 ) modulus. However, a minimum in relative transport rate is observed at an apparent loss tangent (tan δ) value of between 0.7 and 0.9. A theoretical model for mucociliary transport is presented. The model predicted a minimum in transport rate at tan δ equal to 1.74 after adjustment for primary variation due to storage modulus (G 1 ) which is in agreement with the observed frog palate transport rate. The model isolates the loss tangent (tan δ) and the magnitude of the complex modulus (|G*|) as the important viscoelastic parameters for mucociliary transport. Optimum rheological characteristics with respect to slow transport rate can be achieved by using hydrophilic polymer gels with a large complex modulus and simultaneously with a loss tangent equal to 1.74. | en_US |
dc.format.extent | 1143959 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media | en_US |
dc.subject.other | Biomedical Engineering | en_US |
dc.subject.other | Medical Law | en_US |
dc.subject.other | Theoretical Modeling of Mucociliary Transport | en_US |
dc.subject.other | Pharmacy | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Mucociliary Transport | en_US |
dc.subject.other | Viscoelastic Property | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.subject.other | Frog Palate | en_US |
dc.title | The Role of Rheological Properties in Mucociliary Transport by Frog Palate Ciliated Model | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, Michigan, 48109-1065 | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, Michigan, 48109-1065 | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, Michigan, 48109-1065 | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, Michigan, 48109-1065 | en_US |
dc.contributor.affiliationother | Rugby-Darby Group Companies, Inc., Rockville Center, New York, 11570 | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 7899245 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/41438/1/11095_2004_Article_304710.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1023/A:1018927719656 | en_US |
dc.identifier.source | Pharmaceutical Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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