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Human Jejunal Permeability of Two Polar Drugs: Cimetidine and Ranitidine

dc.contributor.authorLennernäs, Hansen_US
dc.contributor.authorYamamoto, Ryuzoen_US
dc.contributor.authorHussain, Ajaz S.en_US
dc.contributor.authorTakamatsu, Narushien_US
dc.contributor.authorBarnett, Jeffrey L.en_US
dc.contributor.authorKim, Ok-Namen_US
dc.contributor.authorLipka, Elkeen_US
dc.contributor.authorHayashi, Yayoien_US
dc.contributor.authorWelage, Lynda S.en_US
dc.contributor.authorLesko, Lawrence J.en_US
dc.contributor.authorAmidon, Gordon L.en_US
dc.contributor.authorIdkaidek, Nasir M.en_US
dc.date.accessioned2006-09-08T19:18:32Z
dc.date.available2006-09-08T19:18:32Z
dc.date.issued2001-06en_US
dc.identifier.citationTakamatsu, Narushi; Kim, Ok-Nam; Welage, Lynda S.; Idkaidek, Nasir M.; Hayashi, Yayoi; Barnett, Jeffrey; Yamamoto, Ryuzo; Lipka, Elke; Lennernäs, Hans; Hussain, Ajaz; Lesko, Lawrence; Amidon, Gordon L.; (2001). "Human Jejunal Permeability of Two Polar Drugs: Cimetidine and Ranitidine." Pharmaceutical Research 18(6): 742-744. <http://hdl.handle.net/2027.42/41484>en_US
dc.identifier.issn1573-904Xen_US
dc.identifier.issn0724-8741en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/41484
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=11474776&dopt=citationen_US
dc.description.abstractPurpose . To determine the human jejunal permeability of cimetidine and ranitidine using a regional jejunal perfusion approach, and to integrate such determinations with previous efforts to establish a baseline correlation between permeability and fraction dose absorbed in humans for soluble drugs.en_US
dc.format.extent114064 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherKluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Mediaen_US
dc.subject.otherPharmacology/Toxicologyen_US
dc.subject.otherIntestinal Permeabilityen_US
dc.subject.otherBiopharmaceutic Classification Systemen_US
dc.subject.otherCimetidineen_US
dc.subject.otherDrug Absorptionen_US
dc.subject.otherRanitidineen_US
dc.subject.otherBiomedicineen_US
dc.subject.otherPharmacyen_US
dc.subject.otherMedical Lawen_US
dc.subject.otherBiochemistry, Generalen_US
dc.subject.otherBiomedical Engineeringen_US
dc.titleHuman Jejunal Permeability of Two Polar Drugs: Cimetidine and Ranitidineen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPharmacy and Pharmacologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumMedical School, The University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumCollege of Pharmacy, The University of Michigan, USA; Pharmacy Services, University Hospital, Ann Arbor, Michigan, 48109en_US
dc.contributor.affiliationotherOffice of Research Resources, CDER, FDA, Rockville, Maryland, 20852en_US
dc.contributor.affiliationotherYamanouchi Pharmaceutical Co. Ltd., Shizuoka, Japanen_US
dc.contributor.affiliationotherSookmyung Women' University, Seoul, 140-742, Koreaen_US
dc.contributor.affiliationotherOffice of Research Resources, CDER, FDA, Rockville, Maryland, 20852en_US
dc.contributor.affiliationotherSchool of Pharmacy, Uppsala University, Uppsala, Swedenen_US
dc.contributor.affiliationotherOffice of Clinical Pharmacology and Biopharmaceutics, CDER, FDA, Rockville, Maryland, 20852en_US
dc.contributor.affiliationotherNagoya City University, Aichi, Japanen_US
dc.contributor.affiliationotherJordan University of Science and Technology, Irbid, Jordanen_US
dc.contributor.affiliationotherOno Pharmaceutical Co. Ltd., c, Osaka, Japan, 618en_US
dc.contributor.affiliationotherPfizer Global R&D, Ann Arbor, Michigan, 48105en_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid11474776en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/41484/1/11095_2004_Article_302739.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1023/A:1011020025338en_US
dc.identifier.sourcePharmaceutical Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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