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Physicochemical Characterization and Solubility Analysis of Thalidomide and Its N-Alkyl Analogs
dc.contributor.authorGoosen, Colleenen_US
dc.contributor.authorFlynn, Gordon L.en_US
dc.contributor.authorLaing, Timothy J.en_US
dc.contributor.authorPlessis, Jeanetta duen_US
dc.contributor.authorGoosen, Theunis C.en_US
dc.date.accessioned2006-09-08T19:18:52Z
dc.date.available2006-09-08T19:18:52Z
dc.date.issued2002-01en_US
dc.identifier.citationGoosen, Colleen; Laing, Timothy J.; Plessis, Jeanetta du; Goosen, Theunis C.; Flynn, Gordon L.; (2002). "Physicochemical Characterization and Solubility Analysis of Thalidomide and Its N-Alkyl Analogs." Pharmaceutical Research 19(1): 13-19. <http://hdl.handle.net/2027.42/41489>en_US
dc.identifier.issn1573-904Xen_US
dc.identifier.issn0724-8741en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/41489
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=11837695&dopt=citationen_US
dc.description.abstractPurpose . The present study was primarily aimed at exploring the feasibility of improving percutaneous delivery via chemical manipulation of the thalidomide molecule to form analogs with improved physicochemical properties. N -Alkyl analogs were synthesized with the belief that these would be suitably hydrophobic and far less crystalline than the reference compound. This article presents their physicochemical properties.en_US
dc.format.extent190173 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherKluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Mediaen_US
dc.subject.otherBiomedicineen_US
dc.subject.otherMedical Lawen_US
dc.subject.otherBiomedical Engineeringen_US
dc.subject.otherSolubility Parameteren_US
dc.subject.otherBiochemistry, Generalen_US
dc.subject.otherPharmacology/Toxicologyen_US
dc.subject.otherN -Alkyl Analogsen_US
dc.subject.otherThalidomideen_US
dc.subject.otherSolubilityen_US
dc.subject.otherLipophilicityen_US
dc.subject.otherPharmacyen_US
dc.titlePhysicochemical Characterization and Solubility Analysis of Thalidomide and Its N-Alkyl Analogsen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPharmacy and Pharmacologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pharmacology, School of Pharmacy, Potchefstroom, University for Christian Higher Education, Potchefstroom, 2520, Republic of South Africa; Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, 48109en_US
dc.contributor.affiliationumCollege of Pharmacy, University of Michigan, Ann Arbor, Michigan, 48109en_US
dc.contributor.affiliationumDepartment of Pharmaceutics, School of Pharmacy, Potchefstroom, University for Christian Higher Education, Potchefstroom, 2520, Republic of South Africa; College of Pharmacy, University of Michigan, Ann Arbor, Michigan, 48109en_US
dc.contributor.affiliationumDepartment of Rheumatology, University of Michigan, Ann Arbor, Michigan, 48109en_US
dc.contributor.affiliationotherDepartment of Pharmaceutics, School of Pharmacy, Potchefstroom, University for Christian Higher Education, Potchefstroom, 2520, Republic of South Africaen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid11837695en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/41489/1/11095_2004_Article_364706.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1023/A:1013643013244en_US
dc.identifier.sourcePharmaceutical Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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