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Human Jejunal Permeability of Cyclosporin A: Influence of Surfactants on P-Glycoprotein Efflux in Caco-2 Cells
dc.contributor.authorChiu, Yu-Yuanen_US
dc.contributor.authorWelage, Lynda S.en_US
dc.contributor.authorAmidon, Gordon L.en_US
dc.contributor.authorNeudeck, Brien L.en_US
dc.contributor.authorHigaki, Kazutakaen_US
dc.contributor.authorBarnett, Jeffrey L.en_US
dc.date.accessioned2006-09-08T19:19:19Z
dc.date.available2006-09-08T19:19:19Z
dc.date.issued2003-05en_US
dc.identifier.citationChiu, Yu-Yuan; Higaki, Kazutaka; Neudeck, Brien L.; Barnett, Jeffrey L.; Welage, Lynda S.; Amidon, Gordon L.; (2003). "Human Jejunal Permeability of Cyclosporin A: Influence of Surfactants on P-Glycoprotein Efflux in Caco-2 Cells." Pharmaceutical Research 20(5): 749-756. <http://hdl.handle.net/2027.42/41496>en_US
dc.identifier.issn0724-8741en_US
dc.identifier.issn1573-904Xen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/41496
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12751630&dopt=citationen_US
dc.description.abstractPurpose. The purpose of this work was to determine the jejunal permeability of cyclosporin A (CsA) in humans and whether formulation variables modulate the effects of P-glycoprotein (P-gp) on the permeability of CsA in Caco-2 cells.en_US
dc.format.extent181859 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherKluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Mediaen_US
dc.subject.otherBiochemistry, Generalen_US
dc.subject.otherBiomedicineen_US
dc.subject.otherCaco-2 Cell Cultureen_US
dc.subject.otherCyclosporin Aen_US
dc.subject.otherPharmacology/Toxicologyen_US
dc.subject.otherP-glycoproteinen_US
dc.subject.otherBiomedical Engineeringen_US
dc.subject.otherMedical Lawen_US
dc.subject.otherPharmacyen_US
dc.subject.otherBiopharmaceutic Classification Systemen_US
dc.subject.otherIntestinal Permeabilityen_US
dc.titleHuman Jejunal Permeability of Cyclosporin A: Influence of Surfactants on P-Glycoprotein Efflux in Caco-2 Cellsen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPharmacy and Pharmacologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumCollege of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor, Michigan, 48109en_US
dc.contributor.affiliationumCollege of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor, Michigan, 48109; Pharmacy Services, University Hospitals, University of Michigan, Ann Arbor, Michigan, 48109en_US
dc.contributor.affiliationumCollege of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor, Michigan, 48109en_US
dc.contributor.affiliationumCollege of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor, Michigan, 48109; Pharmacy Services, University Hospitals, University of Michigan, Ann Arbor, Michigan, 48109en_US
dc.contributor.affiliationumCollege of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor, Michigan, 48109; Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, Okayama, 700-8350, Japanen_US
dc.contributor.affiliationumDepartment of Internal Medicine, Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, Michigan, 48109en_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid12751630en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/41496/1/11095_2004_Article_464398.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1023/A:1023481418576en_US
dc.identifier.sourcePharmaceutical Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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