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Amino Acid Ester Prodrugs of Floxuridine: Synthesis and Effects of Structure, Stereochemistry, and Site of Esterification on the Rate of Hydrolysis
dc.contributor.authorVig, Balvinder S.en_US
dc.contributor.authorMittal, Sachinen_US
dc.contributor.authorLandowski, Christopher P.en_US
dc.contributor.authorShin, Ho-Chulen_US
dc.contributor.authorHilfinger, John M.en_US
dc.contributor.authorMosberg, Henry I.en_US
dc.contributor.authorLorenzi, Philip J.en_US
dc.contributor.authorAmidon, Gordon L.en_US
dc.date.accessioned2006-09-08T19:19:42Z
dc.date.available2006-09-08T19:19:42Z
dc.date.issued2003-09en_US
dc.identifier.citationVig, Balvinder S.; Lorenzi, Philip J.; Mittal, Sachin; Landowski, Christopher P.; Shin, Ho-Chul; Mosberg, Henry I.; Hilfinger, John M.; Amidon, Gordon L.; (2003). "Amino Acid Ester Prodrugs of Floxuridine: Synthesis and Effects of Structure, Stereochemistry, and Site of Esterification on the Rate of Hydrolysis." Pharmaceutical Research 20(9): 1381-1388. <http://hdl.handle.net/2027.42/41502>en_US
dc.identifier.issn1573-904Xen_US
dc.identifier.issn0724-8741en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/41502
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=14567631&dopt=citationen_US
dc.description.abstractPurpose . To synthesize amino acid ester prodrugs of floxuridine (FUdR) and to investigate the effects of structure, stereochemistry, and site of esterification of promoiety on the rates of hydrolysis of these prodrugs in Caco-2 cell homogenates.en_US
dc.format.extent105948 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherKluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Mediaen_US
dc.subject.otherAmino Aciden_US
dc.subject.otherPharmacology/Toxicologyen_US
dc.subject.otherStabilityen_US
dc.subject.otherBiochemistry, Generalen_US
dc.subject.otherMedical Lawen_US
dc.subject.otherBiomedical Engineeringen_US
dc.subject.otherProdrugen_US
dc.subject.otherHydrolysisen_US
dc.subject.otherFloxuridineen_US
dc.subject.otherPharmacyen_US
dc.subject.otherCaco-2en_US
dc.subject.otherBiomedicineen_US
dc.titleAmino Acid Ester Prodrugs of Floxuridine: Synthesis and Effects of Structure, Stereochemistry, and Site of Esterification on the Rate of Hydrolysisen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPharmacy and Pharmacologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, 48109en_US
dc.contributor.affiliationumDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, 48109en_US
dc.contributor.affiliationumDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, 48109en_US
dc.contributor.affiliationumDepartment of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, 48109en_US
dc.contributor.affiliationumDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, 48109en_US
dc.contributor.affiliationumDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, 48109en_US
dc.contributor.affiliationumDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, 48109en_US
dc.contributor.affiliationotherTSRL Inc., Ann Arbor, MI, 48108en_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid14567631en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/41502/1/11095_2004_Article_471011.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1023/A:1025745824632en_US
dc.identifier.sourcePharmaceutical Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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