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Floxuridine Amino Acid Ester Prodrugs: Enhancing Caco-2 Permeability and Resistance to Glycosidic Bond Metabolism
dc.contributor.authorAmidon, Gordon L.en_US
dc.contributor.authorSong, Xueqinen_US
dc.contributor.authorLorenzi, Philip L.en_US
dc.contributor.authorHilfinger, John M.en_US
dc.contributor.authorLandowski, Christopher P.en_US
dc.date.accessioned2006-09-08T19:20:13Z
dc.date.available2006-09-08T19:20:13Z
dc.date.issued2005-09en_US
dc.identifier.citationLandowski, Christopher P.; Song, Xueqin; Lorenzi, Philip L.; Hilfinger, John M.; Amidon, Gordon L.; (2005). "Floxuridine Amino Acid Ester Prodrugs: Enhancing Caco-2 Permeability and Resistance to Glycosidic Bond Metabolism." Pharmaceutical Research 22(9): 1510-1518. <http://hdl.handle.net/2027.42/41510>en_US
dc.identifier.issn0724-8741en_US
dc.identifier.issn1573-904Xen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/41510
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16132363&dopt=citationen_US
dc.description.abstractThe aim of this study was to synthesize amino acid ester prodrugs of 5-fluoro-2′-deoxyuridine (floxuridine) to enhance intestinal absorption and resistance to glycosidic bond metabolism.en_US
dc.format.extent454326 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherSpringer-Verlag; Springer Science + Business Media, Inc.en_US
dc.subject.otherPharmacyen_US
dc.subject.otherBiomedical Engineeringen_US
dc.subject.otherBiomedicineen_US
dc.subject.otherPEPT1en_US
dc.subject.otherFloxuridine Prodrugsen_US
dc.subject.otherPharmacology/Toxicologyen_US
dc.subject.otherMetabolismen_US
dc.subject.otherBiochemistry, Generalen_US
dc.subject.otherCaco-2 Permeabilityen_US
dc.subject.otherThymidine Phosphorylaseen_US
dc.subject.otherMedical Lawen_US
dc.titleFloxuridine Amino Acid Ester Prodrugs: Enhancing Caco-2 Permeability and Resistance to Glycosidic Bond Metabolismen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPharmacy and Pharmacologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, 48109-1065, USAen_US
dc.contributor.affiliationumDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, 48109-1065, USAen_US
dc.contributor.affiliationumDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, 48109-1065, USAen_US
dc.contributor.affiliationumDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, 48109-1065, USAen_US
dc.contributor.affiliationotherTSRL, Inc., 540 Avis Drive, Suite A, Ann Arbor, Michigan, 48108, USAen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid16132363en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/41510/1/11095_2005_Article_6156.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/s11095-005-6156-9en_US
dc.identifier.sourcePharmaceutical Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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