Estimating Human Oral Fraction Dose Absorbed: A Correlation Using Rat Intestinal Membrane Permeability for Passive and Carrier-Mediated Compounds
dc.contributor.author | Fleisher, David | en_US |
dc.contributor.author | Amidon, Gordon L. | en_US |
dc.contributor.author | Sinko, Patrick J. | en_US |
dc.date.accessioned | 2006-09-08T19:20:44Z | |
dc.date.available | 2006-09-08T19:20:44Z | |
dc.date.issued | 1988-10 | en_US |
dc.identifier.citation | Amidon, Gordon L.; Sinko, Patrick J.; Fleisher, David; (1988). "Estimating Human Oral Fraction Dose Absorbed: A Correlation Using Rat Intestinal Membrane Permeability for Passive and Carrier-Mediated Compounds." Pharmaceutical Research 5(10): 651-654. <http://hdl.handle.net/2027.42/41518> | en_US |
dc.identifier.issn | 1573-904X | en_US |
dc.identifier.issn | 0724-8741 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/41518 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3244618&dopt=citation | en_US |
dc.description.abstract | Based on a simple tube model for drug absorption, the key parameters controlling drug absorption are shown to be the dimensionless effective permeability, P eff * , and the Graetz number, Gz , when metabolism or solubility/dissolution is not rate controlling. Estimating the Graetz number in humans and assuming that P aq * is not rate controlling gives the following equation for fraction dose absorbed: F = 1− e −2 P*w . The correlation between fraction dose absorbed in humans and P w * determined from steady-state perfused rat intestinal segments gives an excellent correlation. It is of particular significance that the correlation includes drugs that are absorbed by passive and carrier-mediated processes. This indicates that P w * is one of the key variables controlling oral drug absorption and that the correlation may be useful for estimating oral drug absorption in humans regardless of the mechanism of absorption. | en_US |
dc.format.extent | 546115 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media | en_US |
dc.subject.other | Permeability | en_US |
dc.subject.other | Carrier-mediated Absorption | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Fraction Dose Absorbed | en_US |
dc.subject.other | Pharmacy | en_US |
dc.subject.other | Biomedical Engineering | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Medical Law | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.subject.other | Film Model | en_US |
dc.subject.other | Passive Absorption | en_US |
dc.title | Estimating Human Oral Fraction Dose Absorbed: A Correlation Using Rat Intestinal Membrane Permeability for Passive and Carrier-Mediated Compounds | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | College of Pharmacy, The University of Michigan, Ann Arbor, Michigan, 48109-1065 | en_US |
dc.contributor.affiliationum | College of Pharmacy, The University of Michigan, Ann Arbor, Michigan, 48109-1065 | en_US |
dc.contributor.affiliationum | College of Pharmacy, The University of Michigan, Ann Arbor, Michigan, 48109-1065 | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 3244618 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/41518/1/11095_2004_Article_306264.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1023/A:1015927004752 | en_US |
dc.identifier.source | Pharmaceutical Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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