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The Estimation of Solubility in Binary Solvents: Application of the Reduced 3-Suffix Solubility Equation to Ethanol–Water Mixtures

dc.contributor.authorAmidon, Gordon L.en_US
dc.contributor.authorWilliams, N. Adeyinkaen_US
dc.date.accessioned2006-09-08T19:20:56Z
dc.date.available2006-09-08T19:20:56Z
dc.date.issued1988-03en_US
dc.identifier.citationWilliams, N. Adeyinka; Amidon, Gordon L.; (1988). "The Estimation of Solubility in Binary Solvents: Application of the Reduced 3-Suffix Solubility Equation to Ethanol–Water Mixtures." Pharmaceutical Research 5(3): 193-195. <http://hdl.handle.net/2027.42/41521>en_US
dc.identifier.issn0724-8741en_US
dc.identifier.issn1573-904Xen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/41521
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3244634&dopt=citationen_US
dc.description.abstractThe reduced 3-suffix solubility equation (R3SSE) is applied to the characterization of solubility in the ethanol–water system. The data needed are the solubility of the compound in each of the pure solvents and at one ethanol–water composition. This composition has been estimated from solubility data to be 0.56 volume fraction of ethanol. The solubility obtained at this volume fraction is used to estimate the ternary solute–solvent interaction constant, C 2 . The R3SSE, with the C 2 thus obtained, predicts the mixed solvent solubilities of the compounds tested, as accurately as that obtained from several volume fractions. The superiority of the R3SSE over two related equations—a simple second-degree polynomial equation and a simplified form of the R3SSE which neglects contributions to solubility from the solvent mixture—is also demonstrated for a number of solutes.en_US
dc.format.extent480524 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherKluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Mediaen_US
dc.subject.otherMixed Solventsen_US
dc.subject.otherEthanol–Wateren_US
dc.subject.otherMedical Lawen_US
dc.subject.otherBiomedical Engineeringen_US
dc.subject.otherReduced 3-suffix Solubility Equationen_US
dc.subject.otherBiochemistry, Generalen_US
dc.subject.otherPharmacyen_US
dc.subject.otherBiomedicineen_US
dc.subject.otherPharmacology/Toxicologyen_US
dc.titleThe Estimation of Solubility in Binary Solvents: Application of the Reduced 3-Suffix Solubility Equation to Ethanol–Water Mixturesen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPharmacy and Pharmacologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumCollege of Pharmacy, The University of Michigan, Ann Arbor, Michigan, 48109-1065en_US
dc.contributor.affiliationumCollege of Pharmacy, The University of Michigan, Ann Arbor, Michigan, 48109-1065en_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid3244634en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/41521/1/11095_2004_Article_306166.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1023/A:1015925225766en_US
dc.identifier.sourcePharmaceutical Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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