The Estimation of Solubility in Binary Solvents: Application of the Reduced 3-Suffix Solubility Equation to Ethanol–Water Mixtures
dc.contributor.author | Amidon, Gordon L. | en_US |
dc.contributor.author | Williams, N. Adeyinka | en_US |
dc.date.accessioned | 2006-09-08T19:20:56Z | |
dc.date.available | 2006-09-08T19:20:56Z | |
dc.date.issued | 1988-03 | en_US |
dc.identifier.citation | Williams, N. Adeyinka; Amidon, Gordon L.; (1988). "The Estimation of Solubility in Binary Solvents: Application of the Reduced 3-Suffix Solubility Equation to Ethanol–Water Mixtures." Pharmaceutical Research 5(3): 193-195. <http://hdl.handle.net/2027.42/41521> | en_US |
dc.identifier.issn | 0724-8741 | en_US |
dc.identifier.issn | 1573-904X | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/41521 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3244634&dopt=citation | en_US |
dc.description.abstract | The reduced 3-suffix solubility equation (R3SSE) is applied to the characterization of solubility in the ethanol–water system. The data needed are the solubility of the compound in each of the pure solvents and at one ethanol–water composition. This composition has been estimated from solubility data to be 0.56 volume fraction of ethanol. The solubility obtained at this volume fraction is used to estimate the ternary solute–solvent interaction constant, C 2 . The R3SSE, with the C 2 thus obtained, predicts the mixed solvent solubilities of the compounds tested, as accurately as that obtained from several volume fractions. The superiority of the R3SSE over two related equations—a simple second-degree polynomial equation and a simplified form of the R3SSE which neglects contributions to solubility from the solvent mixture—is also demonstrated for a number of solutes. | en_US |
dc.format.extent | 480524 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media | en_US |
dc.subject.other | Mixed Solvents | en_US |
dc.subject.other | Ethanol–Water | en_US |
dc.subject.other | Medical Law | en_US |
dc.subject.other | Biomedical Engineering | en_US |
dc.subject.other | Reduced 3-suffix Solubility Equation | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.subject.other | Pharmacy | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.title | The Estimation of Solubility in Binary Solvents: Application of the Reduced 3-Suffix Solubility Equation to Ethanol–Water Mixtures | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | College of Pharmacy, The University of Michigan, Ann Arbor, Michigan, 48109-1065 | en_US |
dc.contributor.affiliationum | College of Pharmacy, The University of Michigan, Ann Arbor, Michigan, 48109-1065 | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 3244634 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/41521/1/11095_2004_Article_306166.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1023/A:1015925225766 | en_US |
dc.identifier.source | Pharmaceutical Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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