Topical Drug Delivery from Thin Applications: Theoretical Predictions and Experimental Results
dc.contributor.author | Weiner, Norman D. | en_US |
dc.contributor.author | Flynn, Gordon L. | en_US |
dc.contributor.author | Curl, Rane L. | en_US |
dc.contributor.author | Topp, Elizabeth | en_US |
dc.contributor.author | Addicks, William J. | en_US |
dc.date.accessioned | 2006-09-08T19:22:11Z | |
dc.date.available | 2006-09-08T19:22:11Z | |
dc.date.issued | 1990-10 | en_US |
dc.identifier.citation | Addicks, William; Weiner, Norman; Flynn, Gordon; Curl, Rane; Topp, Elizabeth; (1990). "Topical Drug Delivery from Thin Applications: Theoretical Predictions and Experimental Results." Pharmaceutical Research 7(10): 1048-1054. <http://hdl.handle.net/2027.42/41540> | en_US |
dc.identifier.issn | 0724-8741 | en_US |
dc.identifier.issn | 1573-904X | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/41540 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2281035&dopt=citation | en_US |
dc.description.abstract | Stainless-steel templates of various thicknesses (75, 200, 800, and 1600 µm) were used to apply propylene glycol/water gels containing methyl or propyl p -aminobenzoates to silicone rubber membranes, and drug delivery was studied with the use of the Bronaugh diffusion cell under conditions in which the drug was initially in thermodynamic equilibrium with respect to the application and membrane. Theoretical diffusion profiles were generated with the use of a model which assumes that diffusional gradients exist within the application. To use the model equation, previously derived for the initial condition in which the drug is in thermodynamic equilibrium with respect to the application and membrane, drug diffusivity in both the application and the membrane and the drug's membrane/ vehicle partition coefficient were independently determined. In general, agreement between experimental and theoretical results was within 25%. | en_US |
dc.format.extent | 1131817 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media | en_US |
dc.subject.other | Diffusion Cells | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Medical Law | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Topical Delivery | en_US |
dc.subject.other | Biomedical Engineering | en_US |
dc.subject.other | Thin Films | en_US |
dc.subject.other | Flow-through | en_US |
dc.subject.other | Pharmacy | en_US |
dc.title | Topical Drug Delivery from Thin Applications: Theoretical Predictions and Experimental Results | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, Michigan, 48109 | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, Michigan, 48109 | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, Michigan, 48109 | en_US |
dc.contributor.affiliationum | Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan, 48109 | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, Michigan, 48109 | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 2281035 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/41540/1/11095_2004_Article_305860.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1023/A:1015995217820 | en_US |
dc.identifier.source | Pharmaceutical Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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