Absorption of Polyethylene Glycols 600 Through 2000: The Molecular Weight Dependence of Gastrointestinal and Nasal Absorption
dc.contributor.author | Amidon, Gordon L. | en_US |
dc.contributor.author | Flynn, Gordon L. | en_US |
dc.contributor.author | Donovan, Maureen D. | en_US |
dc.date.accessioned | 2006-09-08T19:22:54Z | |
dc.date.available | 2006-09-08T19:22:54Z | |
dc.date.issued | 1990-08 | en_US |
dc.identifier.citation | Donovan, Maureen D.; Flynn, Gordon L.; Amidon, Gordon L.; (1990). "Absorption of Polyethylene Glycols 600 Through 2000: The Molecular Weight Dependence of Gastrointestinal and Nasal Absorption." Pharmaceutical Research 7(8): 863-868. <http://hdl.handle.net/2027.42/41551> | en_US |
dc.identifier.issn | 1573-904X | en_US |
dc.identifier.issn | 0724-8741 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/41551 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2235883&dopt=citation | en_US |
dc.description.abstract | Polyethylene glycols (PEGs) 600,1000, and 2000 were used to study the molecular weight permeability dependence in the rat nasal and gastrointestinal mucosa. Absorption of the PEGs was measured by following their urinary excretion over a 6-hr collection period. HPLC methods were used to separate and quantitate the individual oligomeric species present in the PEG samples. The permeabilities of both the gastrointestinal and the nasal mucosae exhibited similar molecular weight dependencies. The steepest absorption dependence for both mucosae occurs with the oligomers of PEG 600, where the extent of absorption decreases from approximately 60% to near 30% over a molecular weight range of less than 300 daltons. Differences in the absorption characteristics between the two sites appear in the molecular weight range spanned by PEG 1000. For these oligomers, the mean absorption from the nasal cavity is approximately 14%, while that from the gastrointestinal tract is only 9%. For PEG 2000, mean absorption decreases to 4% following intranasal application and below 2% following gastrointestinal administration. Within the PEG 1000 and 2000 samples, however, very little molecular weight dependency is seen among the oligomers. In the range studied, a distinct molecular weight cutoff was not apparent at either site. | en_US |
dc.format.extent | 913064 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media | en_US |
dc.subject.other | Biomedical Engineering | en_US |
dc.subject.other | Permeability | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Medical Law | en_US |
dc.subject.other | Gastrointestinal Absorption | en_US |
dc.subject.other | Molecular Weight Cutoff | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.subject.other | Polyethylene Glycol | en_US |
dc.subject.other | Nasal Absorption | en_US |
dc.subject.other | Molecular Weight-dependent Absorption | en_US |
dc.subject.other | Pharmacy | en_US |
dc.title | Absorption of Polyethylene Glycols 600 Through 2000: The Molecular Weight Dependence of Gastrointestinal and Nasal Absorption | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | College of Pharmacy, The University of Michigan, Ann Arbor, Michigan, 48109-1065 | en_US |
dc.contributor.affiliationum | College of Pharmacy, The University of Michigan, Ann Arbor, Michigan, 48109-1065; College of Pharmacy, The University of Iowa, Iowa City, Iowa, 52242; College of Pharmacy, The University of Iowa, Iowa City, Iowa, 52242 | en_US |
dc.contributor.affiliationum | College of Pharmacy, The University of Michigan, Ann Arbor, Michigan, 48109-1065 | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 2235883 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/41551/1/11095_2004_Article_305824.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1023/A:1015921101465 | en_US |
dc.identifier.source | Pharmaceutical Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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