Viscoelastic Properties of Polyacrylic Acid Gels in Mixed Solvents
dc.contributor.author | Chu, James S. | en_US |
dc.contributor.author | Yu, Danny M. | en_US |
dc.contributor.author | Weiner, Norman D. | en_US |
dc.contributor.author | Goldberg, Arthur H. | en_US |
dc.contributor.author | Amidon, Gordon L. | en_US |
dc.date.accessioned | 2006-09-08T19:24:01Z | |
dc.date.available | 2006-09-08T19:24:01Z | |
dc.date.issued | 1992-12 | en_US |
dc.identifier.citation | Chu, James S.; Yu, Danny M.; Amidon, Gordon L.; Weiner, Norman D.; Goldberg, Arthur H.; (1992). "Viscoelastic Properties of Polyacrylic Acid Gels in Mixed Solvents." Pharmaceutical Research 9(12): 1659-1663. <http://hdl.handle.net/2027.42/41568> | en_US |
dc.identifier.issn | 0724-8741 | en_US |
dc.identifier.issn | 1573-904X | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/41568 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1488414&dopt=citation | en_US |
dc.description.abstract | The objective of this study is to investigate the viscoelastic properties of Carbopol 934P polymeric systems in a variety of mixtures of pharmaceutical solvents. Carbopol 934P neutralized with a 1:1 equivalent ratio of triethanolamine was dissolved in various binary or ternary solvent mixtures consisting of propylene glycol, glycerol formal, and water. Dynamic moduli G′ and G″, complex viscosities, η′ and η″, and loss tangent, tanδ, were examined over a frequency range of 10-3 to 10 Hz using an oscillatory viscoelastic rheometer at 30°C. The results indicated that for 0.5-1.5 wt% neutralized Carbopol in ternary mixtures, G′ and G″ increased by 3-4 orders of magnitude and the phase angle decreased from 80 to 25° when the water content in the solvent mixture increased from 10 to 80 wt%. These studies also indicated that the addition of water to nonaqueous Carbopol 934P polymer systems transforms them from low-viscosity solutions to gels with significant elastic behavior involving physical interaction and entanglement of polymer segments with solvents. | en_US |
dc.format.extent | 688207 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media | en_US |
dc.subject.other | Viscoelasticity | en_US |
dc.subject.other | Biomedical Engineering | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Pharmaceutical Gel Formulation | en_US |
dc.subject.other | Solubility | en_US |
dc.subject.other | Pharmacy | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Carbopol Gel | en_US |
dc.subject.other | Medical Law | en_US |
dc.subject.other | Solvent Effects on Polymer Gel Rheology | en_US |
dc.title | Viscoelastic Properties of Polyacrylic Acid Gels in Mixed Solvents | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, Michigan, 49109-1065; Institute of Pharmaceutical Sciences, Syntex Research, Palo Alto, California, 94304 | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, Michigan, 49109-1065 | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, Michigan, 49109-1065 | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, Michigan, 49109-1065 | en_US |
dc.contributor.affiliationother | Rugby-Darby Group Companies, Inc., Rockville Centre, New York, 11570 | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 1488414 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/41568/1/11095_2004_Article_305348.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1023/A:1015841214591 | en_US |
dc.identifier.source | Pharmaceutical Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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