Structural Specificity of Mucosal-Cell Transport and Metabolism of Peptide Drugs: Implication for Oral Peptide Drug Delivery
dc.contributor.author | Amidon, Gordon L. | en_US |
dc.contributor.author | Bai, Jane P. F. | en_US |
dc.date.accessioned | 2006-09-08T19:24:33Z | |
dc.date.available | 2006-09-08T19:24:33Z | |
dc.date.issued | 1992-08 | en_US |
dc.identifier.citation | Bai, Jane P. F.; Amidon, Gordon L.; (1992). "Structural Specificity of Mucosal-Cell Transport and Metabolism of Peptide Drugs: Implication for Oral Peptide Drug Delivery." Pharmaceutical Research 9(8): 969-978. <http://hdl.handle.net/2027.42/41576> | en_US |
dc.identifier.issn | 0724-8741 | en_US |
dc.identifier.issn | 1573-904X | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/41576 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1409387&dopt=citation | en_US |
dc.description.abstract | The brush border membrane of intestinal mucosal cells contains a peptide carrier system with rather broad substrate specificity and various endo- and exopeptidase activities. Small peptide (di-/ tripeptide)-type drugs with or without an N-terminal α-amino group, including β-lactam antibiotics and angiotensin-converting enzyme (ACE) inhibitors, are transported by the peptide transporter. Poly-peptide drugs are hydrolyzed by brush border membrane proteolytic enzymes to di-/tripeptides and amino acids. Therefore, while the intestinal brush border membrane has a carrier system facilitating the absorption of di-/tripeptide drugs, it is a major barrier limiting oral availability of polypeptide drugs. In this paper, the specificity of peptide transport and metabolism in the intestinal brush border membrane is reviewed. | en_US |
dc.format.extent | 1605850 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Peptide-type Drugs | en_US |
dc.subject.other | Biomedical Engineering | en_US |
dc.subject.other | Brush Border Membrane Peptidases | en_US |
dc.subject.other | β-Lactam Antibiotics | en_US |
dc.subject.other | α-Methyldopa-pro | en_US |
dc.subject.other | Peptide Transporter | en_US |
dc.subject.other | Oral Availability | en_US |
dc.subject.other | Medical Law | en_US |
dc.subject.other | Angiotensin-converting Enzyme (ACE) Inhibitors | en_US |
dc.subject.other | Cytosolic Peptidases | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Aminopeptidase M | en_US |
dc.subject.other | N-terminal α-Amino Group | en_US |
dc.subject.other | Endopeptidase-24.11 | en_US |
dc.subject.other | Pharmacy | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.title | Structural Specificity of Mucosal-Cell Transport and Metabolism of Peptide Drugs: Implication for Oral Peptide Drug Delivery | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, Michigan, 48109-1065 | en_US |
dc.contributor.affiliationother | College of Pharmacy, University of Minnesota, 308 Harvard Street S.E., Minneapolis, Minnesota, 55455 | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 1409387 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/41576/1/11095_2004_Article_305224.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1023/A:1015885823793 | en_US |
dc.identifier.source | Pharmaceutical Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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