Discriminative stimulus effects of a centrally administered, delta-opioid peptide (d-Pen2-d-Pen5-enkephalin) in pigeons
dc.contributor.author | Mosberg, Henry I. | en_US |
dc.contributor.author | Woods, James H. | en_US |
dc.contributor.author | Jewett, D. C. | en_US |
dc.date.accessioned | 2006-09-08T19:49:02Z | |
dc.date.available | 2006-09-08T19:49:02Z | |
dc.date.issued | 1996-10 | en_US |
dc.identifier.citation | Jewett, D. C.; Mosberg, Henry I.; Woods, James H.; (1996). "Discriminative stimulus effects of a centrally administered, delta-opioid peptide (d-Pen2-d-Pen5-enkephalin) in pigeons." Psychopharmacology 127(3): 225-230. <http://hdl.handle.net/2027.42/41956> | en_US |
dc.identifier.issn | 0033-3158 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/41956 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8912400&dopt=citation | en_US |
dc.description.abstract | The present study assessed the discriminative stimulus effects of the delta-opioid agonist [ d -Pen 2 - d -Pen 5 ]enkephalin (DPDPE) in pigeons. Food-restricted pigeons were trained to discriminate between ICV injections of 100 μg [ d -Pen 2 - d -Pen 5 ]enkephalin (DPDPE) and saline in a two-key operant procedure; acquisition of discriminative control was rapid (14–28 daily sessions). [ d -Ser 2 , Leu 5 , Thr 6 ]enkephalin (DSLET) and [ d -Ala 2 ]deltorphin II, peptides selective for delta-opioid receptors, produced discriminative stimulus effects similar to DPDPE, and were approximately equipotent to DPDPE. The non-peptidic, delta-opioid agonist BW373U86 (0.032–100 mg/kg, IM) partially generalized to DPDPE. The kappa-opioid agonist U69,593 (0.01–1 mg/kg, IM), and the mu-opioid agonists, DAMGO (0.1–3.2 μg, ICV) and morphine (1–10 mg/kg, IM), did not produce discriminative stimulus effects similar to DPDPE, up to doses that markedly decreased response rates. Naltrindole (0.1 mg/kg, IM), an antagonist selective for delta-opioid receptors, produced approximately a 30-fold reduction in the potency of DPDPE. DPDPE’s discriminative stimulus effect in pigeons appears to be mediated through a delta-opioid receptor; this effect may provide a procedure for assessing delta-opioid receptor function in vivo. | en_US |
dc.format.extent | 206750 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag; Springer-Verlag Berlin Heidelberg | en_US |
dc.subject.other | BW373U86 | en_US |
dc.subject.other | Operant Behavior | en_US |
dc.subject.other | Pigeons | en_US |
dc.subject.other | Legacy | en_US |
dc.subject.other | [D-Ala2]Deltorphin II | en_US |
dc.subject.other | Thr6]Enkephalin (DSLET) | en_US |
dc.subject.other | Leu5 | en_US |
dc.subject.other | Delta Opioids | en_US |
dc.subject.other | Drug Discrimination | en_US |
dc.subject.other | [D-Ser2 | en_US |
dc.subject.other | Key Words [D-Pen2-D-Pen5]Enkephalin (DPDPE) | en_US |
dc.title | Discriminative stimulus effects of a centrally administered, delta-opioid peptide (d-Pen2-d-Pen5-enkephalin) in pigeons | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan Medical School, 1301 MSRB III, Ann Arbor, MI 48109-0632, USA, US, | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan Medical School, 1301 MSRB III, Ann Arbor, MI 48109-0632, USA, US, | en_US |
dc.contributor.affiliationum | Department of Medicinal Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109-0632, USA, US, | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 8912400 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/41956/1/213-127-3-225_61270225.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s002130050080 | en_US |
dc.identifier.source | Psychopharmacology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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