Methylenetetrahydrofolate reductase and methionine synthase: biochemistry and molecular biology
dc.contributor.author | Matthews, Rowena Green | en_US |
dc.contributor.author | Sheppard, C. | en_US |
dc.contributor.author | Goulding, C. | en_US |
dc.date.accessioned | 2006-09-08T20:08:10Z | |
dc.date.available | 2006-09-08T20:08:10Z | |
dc.date.issued | 1998-03 | en_US |
dc.identifier.citation | Matthews, R. G.; Sheppard, C.; Goulding, C.; (1998). "Methylenetetrahydrofolate reductase and methionine synthase: biochemistry and molecular biology." European Journal of Pediatrics 157(2): S54-S59. <http://hdl.handle.net/2027.42/42254> | en_US |
dc.identifier.issn | 0340-6199 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/42254 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9587027&dopt=citation | en_US |
dc.description.abstract | Methylenetetrahydrofolate reductase and cobalamin-dependent methionine synthase catalyze the penultimate and ultimate steps in the biosynthesis of methionine in prokaryotes, and are required for the regeneration of the methyl group of methionine in mammals. Defects in either of these enzymes can lead to hyperhomocysteinemia. The sequences of the human methylenetetrahydrofolate reductase and methionine synthase are now known, and show clear homology with their bacterial analogues. Mutations in both enzymes that are known to occur in humans and to be associated with hyperhomocysteinemia affect residues that are conserved in the bacterial enzymes. Structure/function studies on the bacterial proteins, summarized in this review, are therefore relevant to the function of the human enzymes; in particular studies on the effects of bacterial mutations analogous to those causing hyperhomocysteinemia in human may shed light on the defects associated with these mutations. | en_US |
dc.format.extent | 317146 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag; Springer-Verlag Berlin Heidelberg | en_US |
dc.subject.other | Vitamin B12 | en_US |
dc.subject.other | Legacy | en_US |
dc.subject.other | Mutations | en_US |
dc.subject.other | Polymorphism | en_US |
dc.subject.other | Cobalamin | en_US |
dc.subject.other | Key Words Hyperhomocysteinemia | en_US |
dc.title | Methylenetetrahydrofolate reductase and methionine synthase: biochemistry and molecular biology | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Pediatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Biophysics Research Division and Department of Biological Chemistry, University of Michigan, 4028 Chemistry, 930 N. University Avenue, Ann Arbor, Michigan, 48109-1055, USA, US | en_US |
dc.contributor.affiliationum | Biophysics Research Division and Department of Biological Chemistry, University of Michigan, 4028 Chemistry, 930 N. University Avenue, Ann Arbor, Michigan, 48109-1055, USA, US | en_US |
dc.contributor.affiliationum | Biophysics Research Division, University of Michigan, 4028 Chemistry, 930 N. University Ave., Ann Arbor, Michigan 48109-1055, USA, e-mail: rmatthew@umich.edu, Fax: (313)764-3323, US | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 9587027 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/42254/1/431-157-S2-S54_8157s054.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/PL00014305 | en_US |
dc.identifier.source | European Journal of Pediatrics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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