Renal transport kinetics of furosemide in the isolated perfused rat kidney
dc.contributor.author | Cook, Jack A. | en_US |
dc.contributor.author | Smith, David E. | en_US |
dc.contributor.author | Lee, Ling-Jar | en_US |
dc.date.accessioned | 2006-09-11T15:35:48Z | |
dc.date.available | 2006-09-11T15:35:48Z | |
dc.date.issued | 1986-04 | en_US |
dc.identifier.citation | Lee, Ling-Jar; Cook, Jack A.; Smith, David E.; (1986). "Renal transport kinetics of furosemide in the isolated perfused rat kidney." Journal of Pharmacokinetics and Biopharmaceutics 14(2): 157-174. <http://hdl.handle.net/2027.42/45036> | en_US |
dc.identifier.issn | 0090-466X | en_US |
dc.identifier.issn | 1573-8744 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/45036 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3746637&dopt=citation | en_US |
dc.description.abstract | Direct quantitative data and corresponding theory are provided for the effect of protein binding on the renal transport of furosemide. Drug studies were performed with various combinations of bovine serum albumin and dextran. This resulted in a percent unbound ( fu ) of furosemide ranging from 0.785 to 85.8%. The corrected renal ( CLr/GFR ) and secretion ( CLs/GFR ) clearances of furosemide were observed to increase with percent free, but in a nonproportional manner. Plots of CLr/GFR or CLs/GFR vs. fu appeared to have a prominent y intercept as well as a convex ascending curve. In addition, the excretion ratio [ ER=CLr/ (fu · GFR) ] was reduced from 60.8 to 8.72 as fu increased. Overall, the data were best fitted to a model in which two Michaelis-Menten terms wre used to describe renal tubular transport, and secretion was dependent upon free drug concentrations in the perfusate. The results demonstrate that the renal mechanisms of furosemide excretion are more complex than previously reported and that active secretion may involve two different transport systems over the concentration range studied. | en_US |
dc.format.extent | 1001884 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media | en_US |
dc.subject.other | Furosemide | en_US |
dc.subject.other | Renal and Secretion Clearances | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Pharmacy | en_US |
dc.subject.other | Veterinary Medicine | en_US |
dc.subject.other | Biomedical Engineering | en_US |
dc.subject.other | Protein Binding | en_US |
dc.subject.other | Excretion Ratio | en_US |
dc.title | Renal transport kinetics of furosemide in the isolated perfused rat kidney | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, 48109-1065, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, 48109-1065, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, 48109-1065, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 3746637 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/45036/1/10928_2005_Article_BF01065259.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF01065259 | en_US |
dc.identifier.source | Journal of Pharmacokinetics and Biopharmaceutics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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