Celiprolol double-peak occurrence and gastric motility: Nonlinear mixed effects modeling of bioavailability data obtained in dogs
dc.contributor.author | Lipka, Elke | en_US |
dc.contributor.author | Lee, I-Der | en_US |
dc.contributor.author | Langguth, Peter | en_US |
dc.contributor.author | Spahn-Langguth, Hildegard | en_US |
dc.contributor.author | Mutschler, Ernst | en_US |
dc.contributor.author | Amidon, Gordon L. | en_US |
dc.date.accessioned | 2006-09-11T15:36:44Z | |
dc.date.available | 2006-09-11T15:36:44Z | |
dc.date.issued | 1995-06 | en_US |
dc.identifier.citation | Lipka, Elke; Lee, I-Der; Langguth, Peter; Spahn-Langguth, Hildegard; Mutschler, Ernst; Amidon, Gordon L.; (1995). "Celiprolol double-peak occurrence and gastric motility: Nonlinear mixed effects modeling of bioavailability data obtained in dogs." Journal of Pharmacokinetics and Biopharmaceutics 23(3): 267-286. <http://hdl.handle.net/2027.42/45049> | en_US |
dc.identifier.issn | 1573-8744 | en_US |
dc.identifier.issn | 0090-466X | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/45049 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8834196&dopt=citation | en_US |
dc.description.abstract | Investigation of the underlying mechanism leading to inter- and intrasubject variations in the plasma concentration-time profiles of drugs (1) can considerably benefit rational drug therapy. The significant effect of gastric emptying on the rate and extent of celiprolol absorption and its role with respect to double-peak formation was demonstrated in the present study. In four dogs racemic celiprolol was dosed perorally in a crossover design during four different phases of the fasted-state gastric cycle and gastric motility was recorded simultaneously using a manometric measurement system. Intravenous doses were also given to obtain disposition and bioavailability parameters. The blood samples were assayed by a stereoselective HPLC method (2). The time to onset of the active phase of the gastric cycle showed an excellent correlation with the time to celiprolol peak concentration. Furthermore, bioavailability was increased when celiprolol was administered during the active phase. Double peaks were observed when the first active phase was relatively short, suggesting that a portion of the drug remained in the stomach until the next active phase. Population pharmacokinetic modeling of the data with a two-compartment open model with two lag times incorporating the motility data confirmed the effect of time to gastric empyting on the variability of the oral pharmacokinetics of celiprolol. The fasted-state motility phases determine the rate and extent of celiprolol absorption and influence the occurrence of double peaks. Peak plasma levels of celiprolol exhibit less variability if lag times, and therefore gastric emptying times, are taken into consideration. | en_US |
dc.format.extent | 966412 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media | en_US |
dc.subject.other | Variable Oral Pharmacokinetics | en_US |
dc.subject.other | NONMEM | en_US |
dc.subject.other | Gastric Motility | en_US |
dc.subject.other | Pharmacy | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Veterinary Medicine | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.subject.other | Biomedical Engineering | en_US |
dc.subject.other | Celiprolol | en_US |
dc.subject.other | Double-peak Phenomenon | en_US |
dc.subject.other | Nonlinear Oral Bioavailability | en_US |
dc.subject.other | Gastric Emptying | en_US |
dc.subject.other | Biomedicine | en_US |
dc.title | Celiprolol double-peak occurrence and gastric motility: Nonlinear mixed effects modeling of bioavailability data obtained in dogs | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, 48109, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, 48109, Ann Arbor, Michigan; Clinical Pharmacology Department, Hoechst-Roussel Pharmaceuticals, Route 202-206, 08876, Somerville, New Jersey | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, 48109, Ann Arbor, Michigan; Department of Pharmacy, ETH, CH-8093, Zuerich, Switzerland | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, 48109, Ann Arbor, Michigan; Department of Pharmacology, Johann Wolfgang Goethe-University, Biocenter, Niederursel, Marie-Curie-Strasse 9, Geb. N260, D-60439, Frankfurt/Main, Germany; TSRL Inc., 540 Avis Drive, Suite A, 48108, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Department of Pharmacology, Johann Wolfgang Goethe-University, Biocenter, Niederursel, Marie-Curie-Strasse 9, Geb. N260, D-60439, Frankfurt/Main, Germany | en_US |
dc.contributor.affiliationother | Department of Pharmacology, Johann Wolfgang Goethe-University, Biocenter, Niederursel, Marie-Curie-Strasse 9, Geb. N260, D-60439, Frankfurt/Main, Germany | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 8834196 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/45049/1/10928_2006_Article_BF02354285.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF02354285 | en_US |
dc.identifier.source | Journal of Pharmacokinetics and Biopharmaceutics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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