Competitive Inhibition of p -Aminohippurate Transport by Quinapril in Rabbit Renal Basolateral Membrane Vesicles
dc.contributor.author | Akarawut, Wiyada | en_US |
dc.contributor.author | Smith, David E. | en_US |
dc.date.accessioned | 2006-09-11T15:37:22Z | |
dc.date.available | 2006-09-11T15:37:22Z | |
dc.date.issued | 1998-06 | en_US |
dc.identifier.citation | Akarawut, Wiyada; Smith, David E.; (1998). "Competitive Inhibition of p -Aminohippurate Transport by Quinapril in Rabbit Renal Basolateral Membrane Vesicles." Journal of Pharmacokinetics and Pharmacodynamics 26(3): 269-287. <http://hdl.handle.net/2027.42/45058> | en_US |
dc.identifier.issn | 0090-466X | en_US |
dc.identifier.issn | 1573-8744 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/45058 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=10098100&dopt=citation | en_US |
dc.description.abstract | The mechanism of quinapril's interaction with the organic anion transporter was characterized by studying its effect on the transport of p -aminohippurate (PAH) in rabbit renal basolateral membrane vesicles (BLMV). Cis-inhibition studies demonstrated that quinapril was a specific and potent inhibitor of PAH. The K i of quinapril was about 20 μM, a value similar to that of probenecid and eight-times lower than the K m value of 165 μM for PAH. Even though quinapril resulted in trans-inhibition of PAH uptake during counterflow studies, kinetic studies revealed that quinapril was a competitive inhibitor of PAH transport. This latter finding suggests that quinapril and PAH share a common binding site on the transporter. Overall, the results indicate that quinapril is a high-affinity inhibitor of the organic anion transporter in renal BLMV, and that drug–drug interactions may occur with other organic anions at the basolateral membrane of proximal cells. | en_US |
dc.format.extent | 989063 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media | en_US |
dc.subject.other | Veterinary Medicine | en_US |
dc.subject.other | Biomedical Engineering | en_US |
dc.subject.other | Kidney | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Pharmacy | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.subject.other | Competitive Inhibition | en_US |
dc.subject.other | P -Aminohippurate | en_US |
dc.subject.other | Quinapril | en_US |
dc.subject.other | Basolateral Membrane Vesicles | en_US |
dc.title | Competitive Inhibition of p -Aminohippurate Transport by Quinapril in Rabbit Renal Basolateral Membrane Vesicles | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | College of Pharmacy and Upjohn Center for Clinical Pharmacology, The University of Michigan, Ann Arbor, 1310 E. Catherine Street, Michigan, 48109–0504 | en_US |
dc.contributor.affiliationum | College of Pharmacy and Upjohn Center for Clinical Pharmacology, The University of Michigan, Ann Arbor, 1310 E. Catherine Street, Michigan, 48109–0504 | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 10098100 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/45058/1/10928_2004_Article_414537.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1023/A:1023281325479 | en_US |
dc.identifier.source | Journal of Pharmacokinetics and Pharmacodynamics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.