Effects of lipid administration on liver apoptotic signals in a mouse model of total parenteral nutrition (TPN)
dc.contributor.author | Drongowski, Robert A. | en_US |
dc.contributor.author | Teitelbaum, Daniel H. | en_US |
dc.contributor.author | Coran, Arnold G. | en_US |
dc.contributor.author | Btaiche, Imad F. | en_US |
dc.contributor.author | Tazuke, Yuko | en_US |
dc.date.accessioned | 2006-09-11T18:39:42Z | |
dc.date.available | 2006-09-11T18:39:42Z | |
dc.date.issued | 2004-04 | en_US |
dc.identifier.citation | Tazuke, Yuko; Drongowski, Robert A.; Btaiche, Imad; Coran, Arnold G.; Teitelbaum, Daniel H.; (2004). "Effects of lipid administration on liver apoptotic signals in a mouse model of total parenteral nutrition (TPN)." Pediatric Surgery International 20(4): 224-228. <http://hdl.handle.net/2027.42/47162> | en_US |
dc.identifier.issn | 1437-9813 | en_US |
dc.identifier.issn | 0179-0358 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/47162 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15034728&dopt=citation | en_US |
dc.description.abstract | Lipids are an important component of total parenteral nutrition (TPN), contributing the largest caloric load per volume of solution and providing essential fatty acids necessary for survival. However, lipids are known to be causative factors in oxidative stress, which are expressed via the Bcl-2 family of proteins and/or Fas-mediated apoptosis in several tissues. Interestingly, we have recently observed an increase in hepatocyte apoptosis with administration of TPN. To address the mechanism of this apoptosis, we investigated the effects of parenteral lipid administration on apoptotic signaling in a mouse model. C57BL/6J male mice received physiologic saline and standard chow (control) or standard TPN solution with (TPN+L) or without lipid (TPN-L) emulsion. After 7 days of infusion, apoptosis increased in the TPN+L at a significantly higher rate compared with control and TPN-L groups ( p <0.05). Both TPN, with and without lipids, suppressed the pro-apoptotic signals Bid and Bcl-xs ( p <0.05). In contrast, TPN with lipid increased the expression of Fas and both the pro-apoptotic factor Bad and the anti-apoptotic factor Bcl-xl ( p <0.05). These changes may contribute to TPN-induced hepatocyte injury (apoptosis) or suppress the ability of liver hepatocytes to regenerate. | en_US |
dc.format.extent | 1556319 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Lipid | en_US |
dc.subject.other | Total Parenteral Nutrition (TPN) | en_US |
dc.subject.other | Hepatocyte | en_US |
dc.subject.other | Medicine | en_US |
dc.subject.other | Apoptosis | en_US |
dc.title | Effects of lipid administration on liver apoptotic signals in a mouse model of total parenteral nutrition (TPN) | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Pediatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Section of Pediatric Surgery, Department of Surgery, University of Michigan Medical School, F3970 Mott Children’s Hospital, Ann Arbor, MI , 48109-0245 , USA | en_US |
dc.contributor.affiliationum | Section of Pediatric Surgery, Department of Surgery, University of Michigan Medical School, F3970 Mott Children’s Hospital, Ann Arbor, MI , 48109-0245 , USA | en_US |
dc.contributor.affiliationum | Section of Pediatric Surgery, Department of Surgery, University of Michigan Medical School, F3970 Mott Children’s Hospital, Ann Arbor, MI , 48109-0245 , USA | en_US |
dc.contributor.affiliationum | Section of Pediatric Surgery, Department of Surgery, University of Michigan Medical School, F3970 Mott Children’s Hospital, Ann Arbor, MI , 48109-0245 , USA | en_US |
dc.contributor.affiliationum | Pharmacy Department, University of Michigan Medical School, Mott Children’s Hospital, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 15034728 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/47162/1/383_2003_Article_1115.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s00383-003-1115-1 | en_US |
dc.identifier.source | Pediatric Surgery International | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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