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Pre dialysis of blood prime in continuous hemodialysis normalizes pH and electrolytes

dc.contributor.authorMottes, Theresa A.en_US
dc.contributor.authorPasko, Deborah A.en_US
dc.contributor.authorMueller, Bruce A.en_US
dc.date.accessioned2006-09-11T19:25:49Z
dc.date.available2006-09-11T19:25:49Z
dc.date.issued2003-11en_US
dc.identifier.citationPasko, Deborah A.; Mottes, Theresa A.; Mueller, Bruce A.; (2003). "Pre dialysis of blood prime in continuous hemodialysis normalizes pH and electrolytes." Pediatric Nephrology 18(11): 1177-1183. <http://hdl.handle.net/2027.42/47820>en_US
dc.identifier.issn1432-198Xen_US
dc.identifier.issn0931-041Xen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/47820
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=14523635&dopt=citationen_US
dc.description.abstractIn critically ill children weighing <10 kg, it is necessary to use blood as a priming solution for the extracorporeal continuous renal replacement therapy (CRRT) circuit before initiating CRRT to prevent hemodilution and maintain adequate oxygenation. However, blood bank blood usually contains supra-physiological electrolyte concentrations and a non-physiological acid-base balance that may exacerbate the patient’s condition. The objective of this trial was to develop a simple protocol to pre-treat blood bank-derived blood to yield a more physiological blood priming solution. Expired human blood in a recirculating in vitro CRRT circuit was dialyzed prior to the initiation of CRRT using a physiological dialysate solution. Serial blood samples were assessed for electrolyte and pH content. Regimens using maximal blood flow rates (180–200 ml/min) and aggressive dialysate flow rates (33–42 ml/min) were able to correct severely hyperkalemic and acidemic blood within 7.5 min. Initially elevated blood potassium concentrations >20 mEq/l were normalized to below 5 mEq/l within 7.5 min of dialysis in all cases. Blood bank-derived blood can be “conditioned” quickly to physiological pH and electrolyte concentrations using these simple pre-dialysis regimens. Unlike some blood preparation regimens that have been published, the technique used in this trial requires no special equipment or added medications that are not already used in CRRT.en_US
dc.format.extent187748 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherSpringer-Verlag; IPNAen_US
dc.subject.otherExtracorporeal Membrane Oxygenationen_US
dc.subject.otherContinuous Renal Replacement Therapyen_US
dc.subject.otherMedicineen_US
dc.subject.otherBlood Primeen_US
dc.titlePre dialysis of blood prime in continuous hemodialysis normalizes pH and electrolytesen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelPediatricsen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumPediatric Dialysis Unit, University of Michigan Health Systems, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationumCollege of Pharmacy, University of Michigan, Michigan, USAen_US
dc.contributor.affiliationumCollege of Pharmacy, University of Michigan, Michigan, USA; Department of Pharmacy Services, B2D301 University Hospital, 1500 E. Medical Center Drive, Ann Arbor, MI 48109–0008, USAen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid14523635en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/47820/1/467_2003_Article_1258.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/s00467-003-1258-2en_US
dc.identifier.sourcePediatric Nephrologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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