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Antibacterial activity of sucralfate versus aluminum chloride in simulated gastric fluid

dc.contributor.authorWelch, K.en_US
dc.contributor.authorCarver, P.en_US
dc.contributor.authorWelage, Lynda S.en_US
dc.date.accessioned2006-09-11T19:31:27Z
dc.date.available2006-09-11T19:31:27Z
dc.date.issued1994-12en_US
dc.identifier.citationWelage, L.; Carver, P.; Welch, K.; (1994). "Antibacterial activity of sucralfate versus aluminum chloride in simulated gastric fluid." European Journal of Clinical Microbiology & Infectious Diseases 13(12): 1046-1052. <http://hdl.handle.net/2027.42/47895>en_US
dc.identifier.issn0934-9723en_US
dc.identifier.issn1435-4373en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/47895
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7889966&dopt=citationen_US
dc.description.abstractStudies have previously demonstrated that sucralfate possesses intrinsic antibacterial activity. This study was designed to indirectly assess whether aluminum is the active antibacterial component of sucralfate and to further evaluate factors that may influence this agent's antibacterial activity. Utilizing an in vitro model, the antibacterial activity of sucralfate, an equivalent quantity of aluminum in the form of aluminum chloride, and a control were compared. In addition, the influences of bacterial species ( Enterobacter cloacae and Pseudomonas aeruginosa ), time (0–24 h) and environmental pH (3, 5, 7) on the agents' antibacterial activities were evaluated. Equivalent quantities of aluminum, as either sucralfate or aluminum chloride, were added to two of three flasks containing approximately 10 5 cfu/ml of bacteria in pH-adjusted simulated gastric fluid. The third flask served as a control. Samples were obtained over 24 h, diluted and subcultured onto agar plates. The experiments demonstrated that bacterial growth was influenced by pH, time and treatment (aluminum chloride or sucralfate). Regardless of pH or bacterial species, bacterial death occurred within 20 min following the addition of aluminum chloride. In contrast, bacterial death following the addition of sucralfate was more variable and appeared to be pH dependent. In conclusion, sucralfate and aluminum chloride both possess antibacterial activity, even at pH values that normally support bacterial growth in gastric fluid. Although differences in the antibacterial activity of the two agents may in part be related to drug-induced changes in pH, these differences also support data suggesting that aluminum release from sucralfate is incomplete and is dependent on pH.en_US
dc.format.extent813407 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherSpringer-Verlag; Friedr. Vieweg & Sohn Verlagsgesellschaft mbHen_US
dc.subject.otherMedical Microbiologyen_US
dc.subject.otherBiomedicineen_US
dc.subject.otherInternal Medicineen_US
dc.titleAntibacterial activity of sucralfate versus aluminum chloride in simulated gastric fluiden_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelMicrobiology and Immunologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumCollege of Pharmacy, University of Michigan, 428 Church Street, 48109-1065, Ann Arbor, Michigan, USA; Department of Pharmacy, University of Michigan Medical Center, University of Michigan, 428 Church Street, 48109-1065, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationumCenter for Statistical Consultation and Research, University of Michigan, 428 Church Street, 48109-1065, Ann Arbor, Michigan, USA; School of Public Health, University of Michigan, 428 Church Street, 48109-1065, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationumCollege of Pharmacy, University of Michigan, 428 Church Street, 48109-1065, Ann Arbor, Michigan, USA; Department of Pharmacy, University of Michigan Medical Center, University of Michigan, 428 Church Street, 48109-1065, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid7889966en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/47895/1/10096_2005_Article_BF02111825.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/BF02111825en_US
dc.identifier.sourceEuropean Journal of Clinical Microbiology & Infectious Diseasesen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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