Diffusion imaging for evaluation of tumor therapies in preclinical animal models
McConville, P. J.; Rehemtulla, Alnawaz; Chenevert, Thomas L.; Moody, J. B.; Stojanovska, Jadranka; Hall, Daniel E.; Moffat, Bradford A.; Ross, Brian D.
2004-12
Citation
Moffat, B. A.; Hall, D. E.; Stojanovska, J.; McConville, P. J.; Moody, J. B.; Chenevert, T. L.; Rehemtulla, A.; Ross, B. D.; (2004). "Diffusion imaging for evaluation of tumor therapies in preclinical animal models." Magnetic Resonance Materials in Physics, Biology and Medicine 17 (3-6): 249-259. <http://hdl.handle.net/2027.42/47951>
Abstract
The increasing development of novel targeted therapies for treating solid tumors has necessitated the development of technology to determine their efficacy in preclinical animal models. One such technology that can non-invasively quantify early changes in tumor cellularity as a result of an efficacious therapy is diffusion MRI. In this overview we present some theories as to the origin of diffusion changes as a result of tumor therapy, a robust methodology for acquisition of apparent diffusion coefficient maps and some applications of determining therapeutic efficacy in a variety therapeutic regimens and animal models.Publisher
Springer-Verlag; ESMRMB
ISSN
1352-8661 0968-5243
Other DOIs
PMID
15580371
Types
Article
URI
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15580371&dopt=citationMetadata
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