Diffusion imaging for evaluation of tumor therapies in preclinical animal models

McConville, P. J.; Rehemtulla, Alnawaz; Chenevert, Thomas L.; Moody, J. B.; Stojanovska, Jadranka; Hall, D. E.; Moffat, Bradford A.; Ross, Brian D.

McConville, P. J.; Rehemtulla, Alnawaz; Chenevert, Thomas L.; Moody, J. B.; Stojanovska, Jadranka; Hall, D. E.; Moffat, Bradford A.; Ross, Brian D.

2004-12

Citation: Moffat, B. A.; Hall, D. E.; Stojanovska, J.; McConville, P. J.; Moody, J. B.; Chenevert, T. L.; Rehemtulla, A.; Ross, B. D.; (2004). "Diffusion imaging for evaluation of tumor therapies in preclinical animal models." Magnetic Resonance Materials in Physics, Biology and Medicine 17 (3-6): 249-259. <http://hdl.handle.net/2027.42/47951>

Abstract: The increasing development of novel targeted therapies for treating solid tumors has necessitated the development of technology to determine their efficacy in preclinical animal models. One such technology that can non-invasively quantify early changes in tumor cellularity as a result of an efficacious therapy is diffusion MRI. In this overview we present some theories as to the origin of diffusion changes as a result of tumor therapy, a robust methodology for acquisition of apparent diffusion coefficient maps and some applications of determining therapeutic efficacy in a variety therapeutic regimens and animal models.

ISSN: 1352-8661, 0968-5243

DOIs: http://dx.doi.org/10.1007/s10334-004-0079-z

PMID: 15580371

URI: http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15580371&dopt=citation

Handle: http://hdl.handle.net/2027.42/47951

Show full item record