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Diffusion imaging for evaluation of tumor therapies in preclinical animal models

dc.contributor.authorMcConville, P. J.en_US
dc.contributor.authorRehemtulla, Alnawazen_US
dc.contributor.authorChenevert, Thomas L.en_US
dc.contributor.authorMoody, J. B.en_US
dc.contributor.authorStojanovska, Jadrankaen_US
dc.contributor.authorHall, Daniel E.en_US
dc.contributor.authorMoffat, Bradford A.en_US
dc.contributor.authorRoss, Brian D.en_US
dc.date.accessioned2006-09-11T19:35:19Z
dc.date.available2006-09-11T19:35:19Z
dc.date.issued2004-12en_US
dc.identifier.citationMoffat, B. A.; Hall, D. E.; Stojanovska, J.; McConville, P. J.; Moody, J. B.; Chenevert, T. L.; Rehemtulla, A.; Ross, B. D.; (2004). "Diffusion imaging for evaluation of tumor therapies in preclinical animal models." Magnetic Resonance Materials in Physics, Biology and Medicine 17 (3-6): 249-259. <http://hdl.handle.net/2027.42/47951>en_US
dc.identifier.issn1352-8661en_US
dc.identifier.issn0968-5243en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/47951
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15580371&dopt=citationen_US
dc.description.abstractThe increasing development of novel targeted therapies for treating solid tumors has necessitated the development of technology to determine their efficacy in preclinical animal models. One such technology that can non-invasively quantify early changes in tumor cellularity as a result of an efficacious therapy is diffusion MRI. In this overview we present some theories as to the origin of diffusion changes as a result of tumor therapy, a robust methodology for acquisition of apparent diffusion coefficient maps and some applications of determining therapeutic efficacy in a variety therapeutic regimens and animal models.en_US
dc.format.extent697655 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherSpringer-Verlag; ESMRMBen_US
dc.subject.otherBiomedical Engineeringen_US
dc.subject.otherComputer Appl. in Life Sciencesen_US
dc.subject.otherSolid State Physics and Spectroscopyen_US
dc.subject.otherMedicine & Public Healthen_US
dc.subject.otherTumoren_US
dc.subject.otherMRIen_US
dc.subject.otherTherapeutic Efficacyen_US
dc.subject.otherDiffusionen_US
dc.subject.otherImaging / Radiologyen_US
dc.subject.otherHealth Informatics & Health Administrationen_US
dc.subject.otherADCen_US
dc.subject.otherPhysiological, Cellular and Medical Topicsen_US
dc.subject.otherApparent Diffusion Coefficienten_US
dc.subject.otherNMRen_US
dc.titleDiffusion imaging for evaluation of tumor therapies in preclinical animal modelsen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPhysicsen_US
dc.subject.hlbsecondlevelElectrical Engineeringen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumCenter for Molecular Imaging, Department of Radiology, , University of Michigan, Ann Arbor, 1150 W. Medical Center Drive, MSRB III Rm 9303, , Ann Arbor, MI, 48109-0503, USAen_US
dc.contributor.affiliationumCenter for Molecular Imaging, Department of Radiology, , University of Michigan, Ann Arbor, 1150 W. Medical Center Drive, MSRB III Rm 9303, , Ann Arbor, MI, 48109-0503, USAen_US
dc.contributor.affiliationumCenter for Molecular Imaging, Department of Radiology, , University of Michigan, Ann Arbor, 1150 W. Medical Center Drive, MSRB III Rm 9303, , Ann Arbor, MI, 48109-0503, USAen_US
dc.contributor.affiliationumCenter for Molecular Imaging, Department of Radiology, , University of Michigan, Ann Arbor, 1150 W. Medical Center Drive, MSRB III Rm 9303, , Ann Arbor, MI, 48109-0503, USAen_US
dc.contributor.affiliationumDepartment of Radiation Oncology, , University of Michigan, Ann Arbor, 1150 W. Medical Center Drive, MSRB III Rm 9303, , Ann Arbor, MI, 48109-0503, USAen_US
dc.contributor.affiliationumCenter for Molecular Imaging, Department of Radiology, , University of Michigan, Ann Arbor, 1150 W. Medical Center Drive, MSRB III Rm 9303, , Ann Arbor, MI, 48109-0503, USAen_US
dc.contributor.affiliationotherMolecular Imaging Research, , 924 N. Main, Ann Arbor, MI, 48104, USAen_US
dc.contributor.affiliationotherMolecular Imaging Research, , 924 N. Main, Ann Arbor, MI, 48104, USAen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid15580371en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/47951/1/10334_2004_Article_79.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/s10334-004-0079-zen_US
dc.identifier.sourceMagnetic Resonance Materials in Physics, Biology and Medicineen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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