Deafness-related decreases in glycine-immunoreactive labeling in the rat cochlear nucleus
Asako, Mikiya; Holt, Avril Genene; Griffith, Ronald D.; Buras, Eric D.; Altschuler, Richard A.
2005-07-01
Citation
Asako, Mikiya; Holt, Avril G.; Griffith, Ronald D.; Buras, Eric D.; Altschuler, Richard A. (2005)."Deafness-related decreases in glycine-immunoreactive labeling in the rat cochlear nucleus." Journal of Neuroscience Research 81(1): 102-109. <http://hdl.handle.net/2027.42/48685>
Abstract
There is increasing evidence of activity-related plasticity in auditory pathways. The present study examined the effects of decreased activity on immunolocalization of the inhibitory neurotransmitter glycine in the cochlear nucleus of the rat after bilateral cochlear ablation. Specifically, glycine-immunoreactive puncta adjacent to somatic profiles were compared in normal hearing animals and animals deafened for 14 days. The number of glycine-immunoreactive puncta surrounding somatic profiles of spherical and globular bushy cells, glycine-immunoreactive type I stellate multipolar cells, radiate neurons (type II stellate multipolar cells), and fusiform cells decreased significantly. In addition, the number of glycine immunopositive tuberculoventral (vertical or corn) cells in the deep layer of the dorsal cochlear nucleus also decreased significantly. These results suggest that decreased inhibition reported in cochlear nucleus after deafness may be due to decreases in glycine. © 2005 Wiley-Liss, Inc.Publisher
Wiley Subscription Services, Inc., A Wiley Company
ISSN
0360-4012 1097-4547
Other DOIs
PMID
15929063
Types
Article
URI
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15929063&dopt=citationMetadata
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