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Deafness-related decreases in glycine-immunoreactive labeling in the rat cochlear nucleus

dc.contributor.authorAsako, Mikiyaen_US
dc.contributor.authorHolt, Avril Geneneen_US
dc.contributor.authorGriffith, Ronald D.en_US
dc.contributor.authorBuras, Eric D.en_US
dc.contributor.authorAltschuler, Richard A.en_US
dc.date.accessioned2006-09-20T15:01:50Z
dc.date.available2006-09-20T15:01:50Z
dc.date.issued2005-07-01en_US
dc.identifier.citationAsako, Mikiya; Holt, Avril G.; Griffith, Ronald D.; Buras, Eric D.; Altschuler, Richard A. (2005)."Deafness-related decreases in glycine-immunoreactive labeling in the rat cochlear nucleus." Journal of Neuroscience Research 81(1): 102-109. <http://hdl.handle.net/2027.42/48685>en_US
dc.identifier.issn0360-4012en_US
dc.identifier.issn1097-4547en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/48685
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15929063&dopt=citationen_US
dc.description.abstractThere is increasing evidence of activity-related plasticity in auditory pathways. The present study examined the effects of decreased activity on immunolocalization of the inhibitory neurotransmitter glycine in the cochlear nucleus of the rat after bilateral cochlear ablation. Specifically, glycine-immunoreactive puncta adjacent to somatic profiles were compared in normal hearing animals and animals deafened for 14 days. The number of glycine-immunoreactive puncta surrounding somatic profiles of spherical and globular bushy cells, glycine-immunoreactive type I stellate multipolar cells, radiate neurons (type II stellate multipolar cells), and fusiform cells decreased significantly. In addition, the number of glycine immunopositive tuberculoventral (vertical or corn) cells in the deep layer of the dorsal cochlear nucleus also decreased significantly. These results suggest that decreased inhibition reported in cochlear nucleus after deafness may be due to decreases in glycine. © 2005 Wiley-Liss, Inc.en_US
dc.format.extent285911 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherNeuroscience, Neurology and Psychiatryen_US
dc.titleDeafness-related decreases in glycine-immunoreactive labeling in the rat cochlear nucleusen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelPsychologyen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelSocial Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumKresge Hearing Research Institute, Department of Otolaryngology/Head Neck Surgery, University of Michigan, Ann Arbor, Michigan ; Department of Otolaryngology/Head Neck Surgery, Kansai Medical University, Osaka, Japanen_US
dc.contributor.affiliationumKresge Hearing Research Institute, Department of Otolaryngology/Head Neck Surgery, University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumKresge Hearing Research Institute, Department of Otolaryngology/Head Neck Surgery, University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumKresge Hearing Research Institute, Department of Otolaryngology/Head Neck Surgery, University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumKresge Hearing Research Institute, Department of Otolaryngology/Head Neck Surgery, University of Michigan, Ann Arbor, Michigan ; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan ; KHRI, University of Michigan, 1301 East Ann, Ann Arbor, MI 48109-0506en_US
dc.identifier.pmid15929063en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/48685/1/20542_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/jnr.20542en_US
dc.identifier.sourceJournal of Neuroscience Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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