Deafness-related decreases in glycine-immunoreactive labeling in the rat cochlear nucleus
dc.contributor.author | Asako, Mikiya | en_US |
dc.contributor.author | Holt, Avril Genene | en_US |
dc.contributor.author | Griffith, Ronald D. | en_US |
dc.contributor.author | Buras, Eric D. | en_US |
dc.contributor.author | Altschuler, Richard A. | en_US |
dc.date.accessioned | 2006-09-20T15:01:50Z | |
dc.date.available | 2006-09-20T15:01:50Z | |
dc.date.issued | 2005-07-01 | en_US |
dc.identifier.citation | Asako, Mikiya; Holt, Avril G.; Griffith, Ronald D.; Buras, Eric D.; Altschuler, Richard A. (2005)."Deafness-related decreases in glycine-immunoreactive labeling in the rat cochlear nucleus." Journal of Neuroscience Research 81(1): 102-109. <http://hdl.handle.net/2027.42/48685> | en_US |
dc.identifier.issn | 0360-4012 | en_US |
dc.identifier.issn | 1097-4547 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/48685 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15929063&dopt=citation | en_US |
dc.description.abstract | There is increasing evidence of activity-related plasticity in auditory pathways. The present study examined the effects of decreased activity on immunolocalization of the inhibitory neurotransmitter glycine in the cochlear nucleus of the rat after bilateral cochlear ablation. Specifically, glycine-immunoreactive puncta adjacent to somatic profiles were compared in normal hearing animals and animals deafened for 14 days. The number of glycine-immunoreactive puncta surrounding somatic profiles of spherical and globular bushy cells, glycine-immunoreactive type I stellate multipolar cells, radiate neurons (type II stellate multipolar cells), and fusiform cells decreased significantly. In addition, the number of glycine immunopositive tuberculoventral (vertical or corn) cells in the deep layer of the dorsal cochlear nucleus also decreased significantly. These results suggest that decreased inhibition reported in cochlear nucleus after deafness may be due to decreases in glycine. © 2005 Wiley-Liss, Inc. | en_US |
dc.format.extent | 285911 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology and Psychiatry | en_US |
dc.title | Deafness-related decreases in glycine-immunoreactive labeling in the rat cochlear nucleus | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, Department of Otolaryngology/Head Neck Surgery, University of Michigan, Ann Arbor, Michigan ; Department of Otolaryngology/Head Neck Surgery, Kansai Medical University, Osaka, Japan | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, Department of Otolaryngology/Head Neck Surgery, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, Department of Otolaryngology/Head Neck Surgery, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, Department of Otolaryngology/Head Neck Surgery, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, Department of Otolaryngology/Head Neck Surgery, University of Michigan, Ann Arbor, Michigan ; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan ; KHRI, University of Michigan, 1301 East Ann, Ann Arbor, MI 48109-0506 | en_US |
dc.identifier.pmid | 15929063 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/48685/1/20542_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/jnr.20542 | en_US |
dc.identifier.source | Journal of Neuroscience Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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