Surface modification of interconnected porous scaffolds

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dc.contributor.author Liu, Xiaohua en_US
dc.contributor.author Won, Youngjun en_US
dc.contributor.author Ma, Peter X. en_US
dc.date.accessioned 2006-09-20T15:03:16Z
dc.date.available 2006-09-20T15:03:16Z
dc.date.issued 2005-07-01 en_US
dc.identifier.citation Liu, Xiaohua; Won, Youngjun; Ma, Peter X. (2005)."Surface modification of interconnected porous scaffolds." Journal of Biomedical Materials Research Part A 74A(1): 84-91. <http://hdl.handle.net/2027.42/48704> en_US
dc.identifier.issn 1549-3296 en_US
dc.identifier.issn 1552-4965 en_US
dc.identifier.uri http://hdl.handle.net/2027.42/48704
dc.description.abstract Surface properties of scaffolds play an important role in cell adhesion and growth. Biodegradable poly(Α-hydroxy acids) have been widely used as scaffolding materials for tissue engineering; however, the lack of functional groups is a limitation. In this work, gelatin was successfully immobilized onto the surface of poly(Α-hydroxy acids) films and porous scaffolds by a new entrapment process. The surface composition and properties were examined using attenuated total reflection–Fourier transform infrared spectroscopy (ATR-FTIR), X-ray photoelectron spectra (XPS), and contact angle measurements. Control over the amount of entrapped gelatin was achieved by varying the solvent composition, the duration of soaking, the concentration of gelatin in solution, and chemical crosslinking. The amount of entrapped gelatin increased with the ratio of dioxane/water in the solvent mixture used. Chemical crosslinking after physical entrapment considerably increased the amount of retained gelatin on the surface of poly(Α-hydroxy acids). Osteoblasts were cultured on these films and scaffolds. The surface modification significantly improved cell attachment and proliferation. Cell numbers on the surface-modified films and scaffolds were significantly higher than those on controls 4 h and 1 day after cell seeding. The osteoblasts showed higher proliferation on surface-modified scaffolds than on the control during 4 weeks of in vitro cultivation. More collagen fibers and other cell secretions were deposited on the surface-modified scaffolds than on the control scaffolds. This novel surface treatment strategy provides a convenient and universal way to modify the surface properties of three-dimensional scaffolds and thus promote cell adhesion and proliferation for tissue engineering. © 2005 Wiley Periodicals, Inc. J Biomed Mater Res, 2005 en_US
dc.format.extent 250425 bytes
dc.format.extent 3118 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.language.iso en_US
dc.publisher Wiley Subscription Services, Inc., A Wiley Company en_US
dc.subject.other Chemistry en_US
dc.subject.other Polymer and Materials Science en_US
dc.title Surface modification of interconnected porous scaffolds en_US
dc.type Article en_US
dc.rights.robots IndexNoFollow en_US
dc.subject.hlbsecondlevel Biomedical Engineering en_US
dc.subject.hlbtoplevel Engineering en_US
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationum Department of Biologic and Materials Sciences, 1011 North University Ave., Room 2211, The University of Michigan, Ann Arbor, Michigan 48109-1078 en_US
dc.contributor.affiliationum Department of Biologic and Materials Sciences, 1011 North University Ave., Room 2211, The University of Michigan, Ann Arbor, Michigan 48109-1078 en_US
dc.contributor.affiliationum Department of Biologic and Materials Sciences, 1011 North University Ave., Room 2211, The University of Michigan, Ann Arbor, Michigan 48109-1078 ; Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109-1078 ; Macromolecular Science and Engineering Center, University of Michigan, Ann Arbor, Michigan 48109-1078 ; Department of Biologic and Materials Sciences, 1011 North University Ave., Room 2211, The University of Michigan, Ann Arbor, Michigan 48109-1078 en_US
dc.description.bitstreamurl http://deepblue.lib.umich.edu/bitstream/2027.42/48704/1/30367_ftp.pdf en_US
dc.identifier.doi http://dx.doi.org/10.1002/jbm.a.30367 en_US
dc.identifier.source Journal of Biomedical Materials Research Part A en_US
dc.owningcollname Interdisciplinary and Peer-Reviewed
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