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dc.contributor.authorMcLean, Samuel A.en_US
dc.contributor.authorWilliams, David A.en_US
dc.contributor.authorHarris, Richard E.en_US
dc.contributor.authorKop, Willem J.en_US
dc.contributor.authorGroner, Kimberly H.en_US
dc.contributor.authorAmbrose, Kirstenen_US
dc.contributor.authorLyden, Angela K.en_US
dc.contributor.authorGracely, Richard H.en_US
dc.contributor.authorCrofford, Leslie J.en_US
dc.contributor.authorGeisser, Michael E.en_US
dc.contributor.authorSen, Anandaen_US
dc.contributor.authorBiswas, Pinakien_US
dc.contributor.authorClauw, Daniel J.en_US
dc.date.accessioned2006-12-07T16:51:15Z
dc.date.available2006-12-07T16:51:15Z
dc.date.issued2005-11en_US
dc.identifier.citationMcLean, Samuel A.; Williams, David A.; Harris, Richard E.; Kop, Willem J.; Groner, Kimberly H.; Ambrose, Kirsten; Lyden, Angela K.; Gracely, Richard H.; Crofford, Leslie J.; Geisser, Michael E.; Sen, Ananda; Biswas, Pinaki; Clauw, Daniel J. (2005)."Momentary relationship between cortisol secretion and symptoms in patients with fibromyalgia Presented in part at the 68th Annual Scientific Meeting of the American College of Rheumatology, San Antonio, TX, October 2004. The opinions and assertions expressed herein are those of the authors and are not to be construed as reflecting the views of the USUHS or the US Department of Defense. ." Arthritis & Rheumatism 52(11): 3660-3669. <http://hdl.handle.net/2027.42/48753>en_US
dc.identifier.issn0004-3591en_US
dc.identifier.issn1529-0131en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/48753
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16258904&dopt=citationen_US
dc.description.abstractObjective To compare the momentary association between salivary cortisol levels and pain, fatigue, and stress symptoms in patients with fibromyalgia (FM), and to compare diurnal cycles of cortisol secretion in patients with FM and healthy control subjects in a naturalistic environment. Methods Twenty-eight patients with FM and 27 healthy control subjects completed assessments on salivary cortisol levels and pain, fatigue, and stress symptoms, 5 times a day for 2 consecutive days, while engaging in usual daily activities. Only those participants who adhered to the protocol (assessed via activity monitor) were included in the final analyses. Results Twenty FM patients and 16 healthy control subjects adhered to the protocol. There were no significant differences in cortisol levels or diurnal cortisol variation between FM patients and healthy controls. Among women with FM, a strong relationship between cortisol level and current pain symptoms was observed at the waking time point ( t = 3.35, P = 0.008) and 1 hour after waking ( t = 2.97, P = 0.011), but not at the later 3 time points. This association was not due to differences in age, number of symptoms of depression, or self-reported history of physical or sexual abuse. Cortisol levels alone explained 38% and 14% of the variation in pain at the waking and 1 hour time points, respectively. No relationship was observed between cortisol level and fatigue or stress symptoms at any of the 5 time points. Conclusion Among women with FM, pain symptoms early in the day are associated with variations in function of the hypothalamic–pituitary–adrenal axis.en_US
dc.format.extent118271 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.titleMomentary relationship between cortisol secretion and symptoms in patients with fibromyalgia Presented in part at the 68th Annual Scientific Meeting of the American College of Rheumatology, San Antonio, TX, October 2004. The opinions and assertions expressed herein are those of the authors and are not to be construed as reflecting the views of the USUHS or the US Department of Defense.en_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelGeriatricsen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumUniversity of Michigan Medical Center, Ann Arbor ; University of Michigan Chronic Pain and Fatigue Research Center, 24 Frank Lloyd Wright Drive, PO Box 385, Ann Arbor, MI 48106en_US
dc.contributor.affiliationumUniversity of Michigan Medical Center, Ann Arbor ; Dr. Williams has received consulting fees (less than $10,000 per year) from Cypress Biosciences and owns stock in Cypress Biosciences. Dr. Gracely has received consulting fees (less than $10,000 per year) from Cypress Biosciences and Pierre Fabre. Dr. Crofford has received consulting fees (less than $10,000 per year) from Pfizer, Wyeth, and Lilly. Dr. Clauw has received consulting fees (more than $10,000 per year) from Cypress Biosciences and owns stock in Cypress Biosciences.en_US
dc.contributor.affiliationumUniversity of Michigan Medical Center, Ann Arboren_US
dc.contributor.affiliationumUniversity of Michigan Medical Center, Ann Arboren_US
dc.contributor.affiliationumUniversity of Michigan Medical Center, Ann Arboren_US
dc.contributor.affiliationumUniversity of Michigan Medical Center, Ann Arboren_US
dc.contributor.affiliationumUniversity of Michigan Medical Center, Ann Arboren_US
dc.contributor.affiliationumUniversity of Michigan Medical Center, Ann Arboren_US
dc.contributor.affiliationumUniversity of Michigan Medical Center, Ann Arboren_US
dc.contributor.affiliationumUniversity of Michigan Medical Center, Ann Arboren_US
dc.contributor.affiliationumUniversity of Michigan Medical Center, Ann Arboren_US
dc.contributor.affiliationotherUniformed Services University of the Health Sciences, Bethesda, Marylanden_US
dc.contributor.affiliationotherUniversity of Kentucky College of Medicine, Lexingtonen_US
dc.identifier.pmid16258904en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/48753/1/21372_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/art.21372en_US
dc.identifier.sourceArthritis & Rheumatismen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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