The expression pattern of Β-catenin in mesothelial proliferative lesions and its diagnostic utilities
Dai, Yiran; Bedrossian, Carlos W. M.; Michael, Claire W.
2005-11
Citation
Dai, Yiran; Bedrossian, Carlos W.M.; Michael, Claire W. (2005)."The expression pattern of Β-catenin in mesothelial proliferative lesions and its diagnostic utilities." Diagnostic Cytopathology 33(5): 320-324. <http://hdl.handle.net/2027.42/48781>
Abstract
Β-Catenin is a component of the E-cadherin-catenin cell adhesion complex. It plays an important role in the Wnt/wg pathway, which conveys critical signals for cell proliferation and transformation. The Β-catenin mutation is an important event in the progression of a number of malignancies. In this study, we evaluated the immunohistochemical (IHC) pattern of Β-catenin in a spectrum of mesothelial lesions. Sixty-five formalin-fixed, paraffin-embedded blocks from 54 serous effusions and 11 pleural biopsies were examined. These cases consisted of 33 invasive mesotheliomas, 9 early mesotheliomas (with negative radiologic finding), so-called mesotheliomas in situ, and 23 reactive mesothelial proliferations. A distinct membranous and/or submembranous staining pattern was seen in 23 cases with normal and reactive mesothelium. In contrast, reduced membranous and/or submembranous antibody staining and markedly increased ectopic cytoplasmic and nuclear staining was seen in 26 cases of 33 mesotheliomas. Seven of 9 early mesotheliomas showed increased ectopic cytoplasmic and/or nuclear stain. On the basis of our findings, identification of Β-catenin staining pattern offers a useful marker in the diagnosis of mesothelial lesions and may help identify neoplastic change. Diagn. Cytopathol. 2005;33:320–324. © 2005 Wiley-Liss, Inc.Publisher
Wiley Subscription Services, Inc., A Wiley Company
ISSN
8755-1039 1097-0339
Other DOIs
PMID
16240396
Types
Article
URI
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16240396&dopt=citationMetadata
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