The expression pattern of Β-catenin in mesothelial proliferative lesions and its diagnostic utilities
dc.contributor.author | Dai, Yiran | en_US |
dc.contributor.author | Bedrossian, Carlos W. M. | en_US |
dc.contributor.author | Michael, Claire W. | en_US |
dc.date.accessioned | 2006-12-07T16:53:37Z | |
dc.date.available | 2006-12-07T16:53:37Z | |
dc.date.issued | 2005-11 | en_US |
dc.identifier.citation | Dai, Yiran; Bedrossian, Carlos W.M.; Michael, Claire W. (2005)."The expression pattern of Β-catenin in mesothelial proliferative lesions and its diagnostic utilities." Diagnostic Cytopathology 33(5): 320-324. <http://hdl.handle.net/2027.42/48781> | en_US |
dc.identifier.issn | 8755-1039 | en_US |
dc.identifier.issn | 1097-0339 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/48781 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16240396&dopt=citation | en_US |
dc.description.abstract | Β-Catenin is a component of the E-cadherin-catenin cell adhesion complex. It plays an important role in the Wnt/wg pathway, which conveys critical signals for cell proliferation and transformation. The Β-catenin mutation is an important event in the progression of a number of malignancies. In this study, we evaluated the immunohistochemical (IHC) pattern of Β-catenin in a spectrum of mesothelial lesions. Sixty-five formalin-fixed, paraffin-embedded blocks from 54 serous effusions and 11 pleural biopsies were examined. These cases consisted of 33 invasive mesotheliomas, 9 early mesotheliomas (with negative radiologic finding), so-called mesotheliomas in situ, and 23 reactive mesothelial proliferations. A distinct membranous and/or submembranous staining pattern was seen in 23 cases with normal and reactive mesothelium. In contrast, reduced membranous and/or submembranous antibody staining and markedly increased ectopic cytoplasmic and nuclear staining was seen in 26 cases of 33 mesotheliomas. Seven of 9 early mesotheliomas showed increased ectopic cytoplasmic and/or nuclear stain. On the basis of our findings, identification of Β-catenin staining pattern offers a useful marker in the diagnosis of mesothelial lesions and may help identify neoplastic change. Diagn. Cytopathol. 2005;33:320–324. © 2005 Wiley-Liss, Inc. | en_US |
dc.format.extent | 352200 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | The expression pattern of Β-catenin in mesothelial proliferative lesions and its diagnostic utilities | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pathology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan, Ann Arbor, Michigan ; University of Michigan Hospital, Department of Pathology, 1500 E. Medical Center Drive, Room 2G332/Box 0054, Ann Arbor, MI 48105 | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Norwegian American Hospital, Chicago, Illinois | en_US |
dc.identifier.pmid | 16240396 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/48781/1/20281_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/dc.20281 | en_US |
dc.identifier.source | Diagnostic Cytopathology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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