Application of selective saturation to image the dynamics of arterial blood flow during brain activation using magnetic resonance imaging
Vazquez, Alberto L.; Lee, Gregory R.; Hernandez-Garcia, Luis; Noll, Douglas C.
2006
Citation
Vazquez, Alberto L.; Lee, Gregory R.; Hernandez-Garcia, Luis; Noll, Douglas C. (2006)."Application of selective saturation to image the dynamics of arterial blood flow during brain activation using magnetic resonance imaging." Magnetic Resonance in Medicine 9999(9999): NA-NA. <http://hdl.handle.net/2027.42/49296>
Abstract
A saturation-based approach is proposed to image the arterial blood flow signal with temporal resolution of 1 to 2 s and in-plane spatial resolution of a few millimeters. Using a saturation approach to suppress the undesired background stationary signal allows the blood water that enters the slice to be imaged at some specified later time. Since the blood protons that are being imaged are not restricted to the intravascular space, this technique is also sensitive to tissue perfusion signal contributions. The signal uptake characteristics of the saturation method proposed were used to study the different signal contributions as a function of the acquisition parameters. A typical perfusion acquisition (FAIR) was also used for comparison. The proposed method was demonstrated in a functional motor activation experiment and the observed signal changes were smaller than those obtained using the FAIR acquisition. The dynamics of the saturation method and FAIR temporal signal changes were investigated and time constants between 2 and 44 s were estimated. The tissue signal contribution to the saturation method's signal was small over the range of acquisition parameters that sensitized it to the arterial compartment. Magn Reson Med, 2006. © 2006 Wiley-Liss, Inc.Publisher
Wiley Subscription Services, Inc., A Wiley Company
ISSN
0740-3194 1522-2594
Other DOIs
Types
Article
Metadata
Show full item recordAccessibility: If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.