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Application of selective saturation to image the dynamics of arterial blood flow during brain activation using magnetic resonance imaging

dc.contributor.authorVazquez, Alberto L.en_US
dc.contributor.authorLee, Gregory R.en_US
dc.contributor.authorHernandez-Garcia, Luisen_US
dc.contributor.authorNoll, Douglas C.en_US
dc.date.accessioned2007-01-17T15:54:29Z
dc.date.available2007-01-17T15:54:29Z
dc.date.issued2006en_US
dc.identifier.citationVazquez, Alberto L.; Lee, Gregory R.; Hernandez-Garcia, Luis; Noll, Douglas C. (2006)."Application of selective saturation to image the dynamics of arterial blood flow during brain activation using magnetic resonance imaging." Magnetic Resonance in Medicine 9999(9999): NA-NA. <http://hdl.handle.net/2027.42/49296>en_US
dc.identifier.issn0740-3194en_US
dc.identifier.issn1522-2594en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/49296
dc.description.abstractA saturation-based approach is proposed to image the arterial blood flow signal with temporal resolution of 1 to 2 s and in-plane spatial resolution of a few millimeters. Using a saturation approach to suppress the undesired background stationary signal allows the blood water that enters the slice to be imaged at some specified later time. Since the blood protons that are being imaged are not restricted to the intravascular space, this technique is also sensitive to tissue perfusion signal contributions. The signal uptake characteristics of the saturation method proposed were used to study the different signal contributions as a function of the acquisition parameters. A typical perfusion acquisition (FAIR) was also used for comparison. The proposed method was demonstrated in a functional motor activation experiment and the observed signal changes were smaller than those obtained using the FAIR acquisition. The dynamics of the saturation method and FAIR temporal signal changes were investigated and time constants between 2 and 44 s were estimated. The tissue signal contribution to the saturation method's signal was small over the range of acquisition parameters that sensitized it to the arterial compartment. Magn Reson Med, 2006. © 2006 Wiley-Liss, Inc.en_US
dc.format.extent862382 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherImagingen_US
dc.titleApplication of selective saturation to image the dynamics of arterial blood flow during brain activation using magnetic resonance imagingen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumFunctional MRI Laboratory, University of Michigan, Ann Arbor, Michigan, USA ; 2360 Bonisteel Boulevard, BIRB, Room 1073, Functional MRI Laboratory, University of Michigan, Ann Arbor, MI 48109-2108, USAen_US
dc.contributor.affiliationumFunctional MRI Laboratory, University of Michigan, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationumFunctional MRI Laboratory, University of Michigan, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationumFunctional MRI Laboratory, University of Michigan, Ann Arbor, Michigan, USAen_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/49296/1/1181_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/mrm.20813en_US
dc.identifier.sourceMagnetic Resonance in Medicineen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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