Show simple item record

dc.contributor.authorCheng, Alanen_US
dc.contributor.authorSaltiel, Alan R.en_US
dc.date.accessioned2007-03-19T17:26:13Z
dc.date.available2007-03-19T17:26:13Z
dc.date.issued2006-03en_US
dc.identifier.citationCheng, Alan; Saltiel, Alan R. (2006)."More TORC for the gluconeogenic engine." BioEssays 28(3): 231-234. <http://hdl.handle.net/2027.42/49523>en_US
dc.identifier.issn0265-9247en_US
dc.identifier.issn1521-1878en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/49523
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16479585&dopt=citationen_US
dc.description.abstractHepatic gluconeogenesis plays a key role in the maintenance of glucose homeostasis. The hormone glucagon stimulates this process, whereas insulin and adiponectin are inhibitory. In a recent report, Koo et al identify the transcriptional regulator TORC2 (Transducer of Regulated CREB activity 2) as a pivotal component of the gluconeogenic program. 1 Both insulin and AMPK increase the phosphorylation of TORC2, while glucagon suppresses it. This in turn regulates the nuclear/cytoplasmic shuttling of TORC2 and its ability to transactivate gluconeogenic genes. Thus, TORC2 might serve as a gluconeogenic “molecular switch” that senses hormones and cellular energy status. BioEssays 28: 231–234, 2006. © 2006 Wiley Periodicals, Inc.en_US
dc.format.extent92903 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherCell & Developmental Biologyen_US
dc.titleMore TORC for the gluconeogenic engineen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartments of Internal Medicine and Physiology, Life Sciences Institute, University of Michigan Medical Center, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartments of Internal Medicine and Physiology, Life Sciences Institute, University of Michigan Medical Center, Ann Arbor, Michigan ; Departments of Internal Medicine and Physiology, Life Sciences Institute, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA.en_US
dc.identifier.pmid16479585en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/49523/1/20375_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/bies.20375en_US
dc.identifier.sourceBioEssaysen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Show simple item record