More TORC for the gluconeogenic engine

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dc.contributor.author Cheng, Alan en_US
dc.contributor.author Saltiel, Alan R. en_US
dc.date.accessioned 2007-03-19T17:26:13Z
dc.date.available 2007-03-19T17:26:13Z
dc.date.issued 2006-03 en_US
dc.identifier.citation Cheng, Alan; Saltiel, Alan R. (2006)."More TORC for the gluconeogenic engine." BioEssays 28(3): 231-234. <http://hdl.handle.net/2027.42/49523> en_US
dc.identifier.issn 0265-9247 en_US
dc.identifier.issn 1521-1878 en_US
dc.identifier.uri http://hdl.handle.net/2027.42/49523
dc.identifier.uri http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16479585&dopt=citation en_US
dc.description.abstract Hepatic gluconeogenesis plays a key role in the maintenance of glucose homeostasis. The hormone glucagon stimulates this process, whereas insulin and adiponectin are inhibitory. In a recent report, Koo et al identify the transcriptional regulator TORC2 (Transducer of Regulated CREB activity 2) as a pivotal component of the gluconeogenic program. 1 Both insulin and AMPK increase the phosphorylation of TORC2, while glucagon suppresses it. This in turn regulates the nuclear/cytoplasmic shuttling of TORC2 and its ability to transactivate gluconeogenic genes. Thus, TORC2 might serve as a gluconeogenic “molecular switch” that senses hormones and cellular energy status. BioEssays 28: 231–234, 2006. © 2006 Wiley Periodicals, Inc. en_US
dc.format.extent 92903 bytes
dc.format.extent 3118 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.publisher Wiley Subscription Services, Inc., A Wiley Company en_US
dc.subject.other Life and Medical Sciences en_US
dc.subject.other Cell & Developmental Biology en_US
dc.title More TORC for the gluconeogenic engine en_US
dc.type Article en_US
dc.rights.robots IndexNoFollow en_US
dc.subject.hlbsecondlevel Ecology and Evolutionary Biology en_US
dc.subject.hlbsecondlevel Molecular, Cellular and Developmental Biology en_US
dc.subject.hlbsecondlevel Natural Resources and Environment en_US
dc.subject.hlbtoplevel Science en_US
dc.subject.hlbtoplevel Health Sciences en_US
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationum Departments of Internal Medicine and Physiology, Life Sciences Institute, University of Michigan Medical Center, Ann Arbor, Michigan en_US
dc.contributor.affiliationum Departments of Internal Medicine and Physiology, Life Sciences Institute, University of Michigan Medical Center, Ann Arbor, Michigan ; Departments of Internal Medicine and Physiology, Life Sciences Institute, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA. en_US
dc.identifier.pmid 16479585 en_US
dc.description.bitstreamurl http://deepblue.lib.umich.edu/bitstream/2027.42/49523/1/20375_ftp.pdf en_US
dc.identifier.doi http://dx.doi.org/10.1002/bies.20375 en_US
dc.identifier.source BioEssays en_US
dc.owningcollname Interdisciplinary and Peer-Reviewed
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