More TORC for the gluconeogenic engine
dc.contributor.author | Cheng, Alan | en_US |
dc.contributor.author | Saltiel, Alan R. | en_US |
dc.date.accessioned | 2007-03-19T17:26:13Z | |
dc.date.available | 2007-03-19T17:26:13Z | |
dc.date.issued | 2006-03 | en_US |
dc.identifier.citation | Cheng, Alan; Saltiel, Alan R. (2006)."More TORC for the gluconeogenic engine." BioEssays 28(3): 231-234. <http://hdl.handle.net/2027.42/49523> | en_US |
dc.identifier.issn | 0265-9247 | en_US |
dc.identifier.issn | 1521-1878 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/49523 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16479585&dopt=citation | en_US |
dc.description.abstract | Hepatic gluconeogenesis plays a key role in the maintenance of glucose homeostasis. The hormone glucagon stimulates this process, whereas insulin and adiponectin are inhibitory. In a recent report, Koo et al identify the transcriptional regulator TORC2 (Transducer of Regulated CREB activity 2) as a pivotal component of the gluconeogenic program. 1 Both insulin and AMPK increase the phosphorylation of TORC2, while glucagon suppresses it. This in turn regulates the nuclear/cytoplasmic shuttling of TORC2 and its ability to transactivate gluconeogenic genes. Thus, TORC2 might serve as a gluconeogenic “molecular switch” that senses hormones and cellular energy status. BioEssays 28: 231–234, 2006. © 2006 Wiley Periodicals, Inc. | en_US |
dc.format.extent | 92903 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cell & Developmental Biology | en_US |
dc.title | More TORC for the gluconeogenic engine | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Departments of Internal Medicine and Physiology, Life Sciences Institute, University of Michigan Medical Center, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Departments of Internal Medicine and Physiology, Life Sciences Institute, University of Michigan Medical Center, Ann Arbor, Michigan ; Departments of Internal Medicine and Physiology, Life Sciences Institute, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA. | en_US |
dc.identifier.pmid | 16479585 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/49523/1/20375_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/bies.20375 | en_US |
dc.identifier.source | BioEssays | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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