Expression of thrombospondin in the adult nervous system
Hoffman, John R.; Dixit, Vishva M.; O'Shea, K. Sue
1994-02-01
Citation
Hoffman, John R.; Dixit, Vishva M.; O'Shea, K. Sue (1994)."Expression of thrombospondin in the adult nervous system." The Journal of Comparative Neurology 340(1): 126-139. <http://hdl.handle.net/2027.42/50059>
Abstract
Thrombospondin (TSP) is an extracellular matrix molecule that has been previously associated with neural development and neurite outgrowth in vitro. Little is known, however, about the expression of TSP in the adult nervous system. In this study, TSP localization was examined in nervous tissue from adult mouse, goldfish, newt, and adult and juvenile Xenopus. TSP was associated with neurons in the brains of all species examined. TSP was present in central nerve tracts capable of regeneration, such as the goldfish, Xenopus, and newt optic nerves, but was absent from tracts not capable of regeneration, such as the mouse optic nerve. TSP was also present in the neuropil of goldfish and newt spinal cord, but was restricted to motor neurons in mice and adult Xenopus. In addition, TSP was observed in sciatic nerves of mice, Xenopus, and newt. These results indicate a correlation between the presence of TSP and the potential for successful nerve regeneration across a wide range of animal classes. © Wiley-Liss, Inc.Publisher
Wiley-Liss, Inc.
ISSN
0021-9967 1096-9861
Other DOIs
PMID
8176001
Types
Article
Metadata
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