Expression of thrombospondin in the adult nervous system
dc.contributor.author | Hoffman, John R. | en_US |
dc.contributor.author | Dixit, Vishva M. | en_US |
dc.contributor.author | O'Shea, K. Sue | en_US |
dc.date.accessioned | 2007-04-06T18:23:01Z | |
dc.date.available | 2007-04-06T18:23:01Z | |
dc.date.issued | 1994-02-01 | en_US |
dc.identifier.citation | Hoffman, John R.; Dixit, Vishva M.; O'Shea, K. Sue (1994)."Expression of thrombospondin in the adult nervous system." The Journal of Comparative Neurology 340(1): 126-139. <http://hdl.handle.net/2027.42/50059> | en_US |
dc.identifier.issn | 0021-9967 | en_US |
dc.identifier.issn | 1096-9861 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/50059 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8176001&dopt=citation | en_US |
dc.description.abstract | Thrombospondin (TSP) is an extracellular matrix molecule that has been previously associated with neural development and neurite outgrowth in vitro. Little is known, however, about the expression of TSP in the adult nervous system. In this study, TSP localization was examined in nervous tissue from adult mouse, goldfish, newt, and adult and juvenile Xenopus. TSP was associated with neurons in the brains of all species examined. TSP was present in central nerve tracts capable of regeneration, such as the goldfish, Xenopus, and newt optic nerves, but was absent from tracts not capable of regeneration, such as the mouse optic nerve. TSP was also present in the neuropil of goldfish and newt spinal cord, but was restricted to motor neurons in mice and adult Xenopus. In addition, TSP was observed in sciatic nerves of mice, Xenopus, and newt. These results indicate a correlation between the presence of TSP and the potential for successful nerve regeneration across a wide range of animal classes. © Wiley-Liss, Inc. | en_US |
dc.format.extent | 2010198 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley-Liss, Inc. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology and Psychiatry | en_US |
dc.title | Expression of thrombospondin in the adult nervous system | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Anatomy and Cell Biology, The University of Michigan, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | Department of Pathology, The University of Michigan, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | Department of Anatomy and Cell Biology, The University of Michigan, Ann Arbor, Michigan 48109 ; Dept. of Anatomy and Cell Biology, University of Michigan, Ann Arbor, MI 48109-0616 | en_US |
dc.identifier.pmid | 8176001 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/50059/1/903400109_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/cne.903400109 | en_US |
dc.identifier.source | The Journal of Comparative Neurology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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