Brain methylation and epileptogenesis: The case of methionine sulfoximine
Sellinger, Otto Z.; Schatz, Robert A.; Porta, Raffaele; Wilens, Timothy E.
1984
Citation
Sellinger, O. Z.; Schatz, R. A.; Porta, R.; Wilens, T. E. (1984)."Brain methylation and epileptogenesis: The case of methionine sulfoximine." Annals of Neurology 16(S1): S115-S120. <http://hdl.handle.net/2027.42/50309>
Abstract
A brief review of the neurochemical effects of the convulsant agent L -methionine- dl -sulfoximine (MSO) on cerebral methylation reactions is presented. Our findings point to the involvement of a number of endogenous methyl acceptor molecules, including histamine, membrane phospholipids, and membrane proteins, in the mediation of the convulsant effect. Our findings also associate the inhibition of methylations by high levels of S -adenosyl- L -homocysteine in brain with protection against MSO-induced seizures. We propose that MSO acts by eliciting the acceleration of a regulatory methylation-demethylation sequence at key molecular sites, including the benzodiazepine receptor complex, which creates an imbalance in this sequence's normal mediation of convulsant–anticonvulsant mechanisms.Publisher
Wiley Subscription Services, Inc., A Wiley Company
ISSN
0364-5134 1531-8249
Other DOIs
PMID
6508248
Types
Article
Metadata
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