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dc.contributor.authorSellinger, Otto Z.en_US
dc.contributor.authorSchatz, Robert A.en_US
dc.contributor.authorPorta, Raffaeleen_US
dc.contributor.authorWilens, Timothy E.en_US
dc.date.accessioned2007-04-06T18:50:15Z
dc.date.available2007-04-06T18:50:15Z
dc.date.issued1984en_US
dc.identifier.citationSellinger, O. Z.; Schatz, R. A.; Porta, R.; Wilens, T. E. (1984)."Brain methylation and epileptogenesis: The case of methionine sulfoximine." Annals of Neurology 16(S1): S115-S120. <http://hdl.handle.net/2027.42/50309>en_US
dc.identifier.issn0364-5134en_US
dc.identifier.issn1531-8249en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/50309
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6508248&dopt=citationen_US
dc.description.abstractA brief review of the neurochemical effects of the convulsant agent L -methionine- dl -sulfoximine (MSO) on cerebral methylation reactions is presented. Our findings point to the involvement of a number of endogenous methyl acceptor molecules, including histamine, membrane phospholipids, and membrane proteins, in the mediation of the convulsant effect. Our findings also associate the inhibition of methylations by high levels of S -adenosyl- L -homocysteine in brain with protection against MSO-induced seizures. We propose that MSO acts by eliciting the acceleration of a regulatory methylation-demethylation sequence at key molecular sites, including the benzodiazepine receptor complex, which creates an imbalance in this sequence's normal mediation of convulsant–anticonvulsant mechanisms.en_US
dc.format.extent579748 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherNeuroscience, Neurology, and Psychiatryen_US
dc.titleBrain methylation and epileptogenesis: The case of methionine sulfoximineen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPsychiatryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumLaboratory of Neurochemistry, Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109 ; Laboratory of Neurochemistry, Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109en_US
dc.contributor.affiliationumLaboratory of Neurochemistry, Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109en_US
dc.contributor.affiliationumLaboratory of Neurochemistry, Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109en_US
dc.contributor.affiliationumLaboratory of Neurochemistry, Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109en_US
dc.identifier.pmid6508248en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/50309/1/410160717_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/ana.410160717en_US
dc.identifier.sourceAnnals of Neurologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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