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dc.contributor.authorYoung, Anne B.en_US
dc.contributor.authorPenney, John B.en_US
dc.contributor.authorStarosta-Rubinstein, Simonen_US
dc.contributor.authorMarkel, Dorene S.en_US
dc.contributor.authorBerent, Stanleyen_US
dc.contributor.authorGiordani, Brunoen_US
dc.contributor.authorEhrenkaufer, Richard E.en_US
dc.contributor.authorJewett, Douglas M.en_US
dc.contributor.authorHichwa, Richarden_US
dc.date.accessioned2007-04-06T18:51:04Z
dc.date.available2007-04-06T18:51:04Z
dc.date.issued1986-09en_US
dc.identifier.citationYoung, Anne B.; Penney, John B.; Starosta-Rubinstein, Simon; Markel, Dorene S.; Berent, Stanley; Giordani, Bruno; Ehrenkaufer, Richard; Jewett, Douglas; Hichwa, Richard (1986)."PET scan investigations of Huntington's disease: Cerebral metabolic correlates of neurological features and functional decline." Annals of Neurology 20(3): 296-303. <http://hdl.handle.net/2027.42/50317>en_US
dc.identifier.issn0364-5134en_US
dc.identifier.issn1531-8249en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/50317
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2945510&dopt=citationen_US
dc.description.abstractFifteen drug-free patients with early to midstage Huntington's disease were evaluated with quantitative neurological examinations, scales for functional capacity, computed tomographic (CT) scans, and positron emission tomographic (PET) scans of 18 F-2-fluoro-2-deoxyglucose ( 18 F-FDG) uptake. All patients had abnormal indices of caudate metabolism on PET scanning, whereas in patients with early disease indices of putamen metabolism and CT measures of caudate atrophy were normal. Indices of caudate metabolism correlated highly with the patients' overall functional capacity ( r = 0.906; p < 0.001) and bradykinesia/rigidity ( r = −0.692; p < 0.01). Indices of putamen metabolism correlated highly with motor functions: Chorea ( r = −0.841; p < 0.01), oculomotor abnormalities ( r = −0.849; p < 0.01), and fine motor coordination ( r = −0.866; p < 0.01). Indices of thalamic metabolism correlated positively with dystonia ( r = 0.559; p < 0.05). The data suggest that PET scanning with 18 F-FDG is a sensitive measure of brain dysfunction in Huntington's disease and that basal ganglia metabolism is highly correlated with the overall functional capacity of individual patients and with the degree of their motor abnormalities.en_US
dc.format.extent1108038 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherNeuroscience, Neurology, and Psychiatryen_US
dc.titlePET scan investigations of Huntington's disease: Cerebral metabolic correlates of neurological features and functional declineen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPsychiatryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartments of Neurology, Psychiatry, Psychology, and Internal Medicine, The University of Michigan, Ann Arbor, MI ; The University of Michigan, Neuroscience Lab Bldg, #1015, 1103 East Huron St, Ann Arbor, MI 48104en_US
dc.contributor.affiliationumDepartments of Neurology, Psychiatry, Psychology, and Internal Medicine, The University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartments of Neurology, Psychiatry, Psychology, and Internal Medicine, The University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartments of Neurology, Psychiatry, Psychology, and Internal Medicine, The University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartments of Neurology, Psychiatry, Psychology, and Internal Medicine, The University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartments of Neurology, Psychiatry, Psychology, and Internal Medicine, The University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartments of Neurology, Psychiatry, Psychology, and Internal Medicine, The University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartments of Neurology, Psychiatry, Psychology, and Internal Medicine, The University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartments of Neurology, Psychiatry, Psychology, and Internal Medicine, The University of Michigan, Ann Arbor, MIen_US
dc.identifier.pmid2945510en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/50317/1/410200305_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/ana.410200305en_US
dc.identifier.sourceAnnals of Neurologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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