PET scan investigations of Huntington's disease: Cerebral metabolic correlates of neurological features and functional decline
dc.contributor.author | Young, Anne B. | en_US |
dc.contributor.author | Penney, John B. | en_US |
dc.contributor.author | Starosta-Rubinstein, Simon | en_US |
dc.contributor.author | Markel, Dorene S. | en_US |
dc.contributor.author | Berent, Stanley | en_US |
dc.contributor.author | Giordani, Bruno | en_US |
dc.contributor.author | Ehrenkaufer, Richard E. | en_US |
dc.contributor.author | Jewett, Douglas M. | en_US |
dc.contributor.author | Hichwa, Richard D. | en_US |
dc.date.accessioned | 2007-04-06T18:51:04Z | |
dc.date.available | 2007-04-06T18:51:04Z | |
dc.date.issued | 1986-09 | en_US |
dc.identifier.citation | Young, Anne B.; Penney, John B.; Starosta-Rubinstein, Simon; Markel, Dorene S.; Berent, Stanley; Giordani, Bruno; Ehrenkaufer, Richard; Jewett, Douglas; Hichwa, Richard (1986)."PET scan investigations of Huntington's disease: Cerebral metabolic correlates of neurological features and functional decline." Annals of Neurology 20(3): 296-303. <http://hdl.handle.net/2027.42/50317> | en_US |
dc.identifier.issn | 0364-5134 | en_US |
dc.identifier.issn | 1531-8249 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/50317 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2945510&dopt=citation | en_US |
dc.description.abstract | Fifteen drug-free patients with early to midstage Huntington's disease were evaluated with quantitative neurological examinations, scales for functional capacity, computed tomographic (CT) scans, and positron emission tomographic (PET) scans of 18 F-2-fluoro-2-deoxyglucose ( 18 F-FDG) uptake. All patients had abnormal indices of caudate metabolism on PET scanning, whereas in patients with early disease indices of putamen metabolism and CT measures of caudate atrophy were normal. Indices of caudate metabolism correlated highly with the patients' overall functional capacity ( r = 0.906; p < 0.001) and bradykinesia/rigidity ( r = −0.692; p < 0.01). Indices of putamen metabolism correlated highly with motor functions: Chorea ( r = −0.841; p < 0.01), oculomotor abnormalities ( r = −0.849; p < 0.01), and fine motor coordination ( r = −0.866; p < 0.01). Indices of thalamic metabolism correlated positively with dystonia ( r = 0.559; p < 0.05). The data suggest that PET scanning with 18 F-FDG is a sensitive measure of brain dysfunction in Huntington's disease and that basal ganglia metabolism is highly correlated with the overall functional capacity of individual patients and with the degree of their motor abnormalities. | en_US |
dc.format.extent | 1108038 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology, and Psychiatry | en_US |
dc.title | PET scan investigations of Huntington's disease: Cerebral metabolic correlates of neurological features and functional decline | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Departments of Neurology, Psychiatry, Psychology, and Internal Medicine, The University of Michigan, Ann Arbor, MI ; The University of Michigan, Neuroscience Lab Bldg, #1015, 1103 East Huron St, Ann Arbor, MI 48104 | en_US |
dc.contributor.affiliationum | Departments of Neurology, Psychiatry, Psychology, and Internal Medicine, The University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Departments of Neurology, Psychiatry, Psychology, and Internal Medicine, The University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Departments of Neurology, Psychiatry, Psychology, and Internal Medicine, The University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Departments of Neurology, Psychiatry, Psychology, and Internal Medicine, The University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Departments of Neurology, Psychiatry, Psychology, and Internal Medicine, The University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Departments of Neurology, Psychiatry, Psychology, and Internal Medicine, The University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Departments of Neurology, Psychiatry, Psychology, and Internal Medicine, The University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Departments of Neurology, Psychiatry, Psychology, and Internal Medicine, The University of Michigan, Ann Arbor, MI | en_US |
dc.identifier.pmid | 2945510 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/50317/1/410200305_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/ana.410200305 | en_US |
dc.identifier.source | Annals of Neurology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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