Positron emission tomographic scan investigations of Huntington's disease: Cerebral metabolic correlates of cognitive function
dc.contributor.author | Berent, Stanley | en_US |
dc.contributor.author | Giordani, Bruno | en_US |
dc.contributor.author | Lehtinen, Shirley | en_US |
dc.contributor.author | Markel, Dorene S. | en_US |
dc.contributor.author | Penney, John B. | en_US |
dc.contributor.author | Buchtel, Henry A. | en_US |
dc.contributor.author | Starosta-Rubinstein, Simon | en_US |
dc.contributor.author | Hichwa, Richard D. | en_US |
dc.contributor.author | Young, Anne B. | en_US |
dc.date.accessioned | 2007-04-06T18:51:44Z | |
dc.date.available | 2007-04-06T18:51:44Z | |
dc.date.issued | 1988-06 | en_US |
dc.identifier.citation | Berent, Stanley; Giordani, Bruno; Lehtinen, Shirley; Markel, Dorene; Penney, John B.; Buchtel, H. A.; Starosta-Rubinstein, Simon; Hichwa, Richard; Young, Anne B. (1988)."Positron emission tomographic scan investigations of Huntington's disease: Cerebral metabolic correlates of cognitive function." Annals of Neurology 23(6): 541-546. <http://hdl.handle.net/2027.42/50323> | en_US |
dc.identifier.issn | 0364-5134 | en_US |
dc.identifier.issn | 1531-8249 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/50323 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2970247&dopt=citation | en_US |
dc.description.abstract | Fifteen drug-free patients with early to mid-stage Huntington's disease (HD) were evaluated with positron emission tomographic (PET) scans of 18 F-2-fluro-2-deoxy- D -glucose uptake and quantitative measures of neurological function, learning, memory, and general intelligence. In comparison with a group of normal volunteers, the HD patients showed lower metabolism in both caudate ( p < 0.001) and putamen ( p < 0.001) on PET scans. A significant and positive relationship was found between neuropsychological measures of verbal learning and memory and caudate metabolism in the patient group but not in the normal group. Visual-spatial learning did not reflect a similar pattern, but performance intelligence quotient was positively related to both caudate and putamen metabolism in the HD group. Vocabulary level was unrelated to either brain structure. Discussion focuses on these and other observed brain-behaviour relationships and on the implications of these findings for general behaviors such as those involved in coping and adaptation. | en_US |
dc.format.extent | 677424 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology, and Psychiatry | en_US |
dc.title | Positron emission tomographic scan investigations of Huntington's disease: Cerebral metabolic correlates of cognitive function | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Psychiatry, University of Michigan, Ann Arbor, MI ; Department of Neurology, University of Michigan, Ann Arbor, MI ; Department of Psychology, University of Michigan, Ann Arbor, MI ; 480 Med Inn Bldg, University of Michigan Hospitals, Ann Arbor, MI 48109-0840 | en_US |
dc.contributor.affiliationum | Department of Psychiatry, University of Michigan, Ann Arbor, MI ; Department of Psychology, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Psychiatry, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Psychiatry, University of Michigan, Ann Arbor, MI ; Department of Neurology, University of Michigan, Ann Arbor, MI ; Veterans Administration Medical Center, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Division of Nuclear Medicine, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan, Ann Arbor, MI | en_US |
dc.identifier.pmid | 2970247 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/50323/1/410230603_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/ana.410230603 | en_US |
dc.identifier.source | Annals of Neurology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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