Motor dysfunction in olivopontocerebellar atrophy is related to cerebral metabolic rate studied with positron emission tomography
dc.contributor.author | Rosenthal, Guy | en_US |
dc.contributor.author | Gilman, Sid | en_US |
dc.contributor.author | Koeppe, Robert A. | en_US |
dc.contributor.author | Kluin, Karen J. | en_US |
dc.contributor.author | Markel, Dorene S. | en_US |
dc.contributor.author | Junck, Larry | en_US |
dc.contributor.author | Gebarski, Stephen S. | en_US |
dc.date.accessioned | 2007-04-06T18:52:09Z | |
dc.date.available | 2007-04-06T18:52:09Z | |
dc.date.issued | 1988-09 | en_US |
dc.identifier.citation | Rosenthal, Guy; Gilman, Sid; Koeppe, Robert A.; Kluin, Karen J.; Markel, Dorene S.; Junck, Larry; Gebarski, Stephen S. (1988)."Motor dysfunction in olivopontocerebellar atrophy is related to cerebral metabolic rate studied with positron emission tomography." Annals of Neurology 24(3): 414-419. <http://hdl.handle.net/2027.42/50327> | en_US |
dc.identifier.issn | 0364-5134 | en_US |
dc.identifier.issn | 1531-8249 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/50327 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3265863&dopt=citation | en_US |
dc.description.abstract | We compared the severity of motor dysfunction with local cerebral metabolic rates for glucose (lCMRGlc) and the; degree of tissue atrophy in 30 patients with olivopontocerebellar atrophy (OPCA). We devised a scale to quantitate the degree of ataxia in the neurological examinations. lCMRGlc was measured with 18 F-2-fluoro-2-deoxy-D-glucose and positron emission tomography (PET). Tissue atrophy was assessed by visual rating of computed tomographic scans. PET studies revealed Marchked hypometabolism in the cerebellar vermis, cerebellar hemispheres, and brainstem of OPCA patients compared with 30 control subjects. A significant correlation was found between severity of motor impairment and lCMRGlc within the cerebellar vermis, both cerebellar hemispheres, and the brainstem. A significant but weaker relationship was noted between the degree of tissue atrophy in these regions and clinical severity. Partial correlation analysis revealed that motor dysfunction in OPCA correlated more strongly with lCMRGlc than with the amount of tissue atrophy. These results suggest that the clinical manifestations of OPCA are more closely related to the metabolic state of the tissue than to the structural changes in the cerebellum. | en_US |
dc.format.extent | 648617 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology, and Psychiatry | en_US |
dc.title | Motor dysfunction in olivopontocerebellar atrophy is related to cerebral metabolic rate studied with positron emission tomography | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Neurology, The University of Michigan, Ann Arbor, MI 48109 | en_US |
dc.contributor.affiliationum | Department of Neurology, The University of Michigan, Ann Arbor, MI 48109 ; The University of Michigan, Department of Neurology, 1914/0316 Taubman Health Care Center, 1500 E Medical Center Dr, Ann Arbor, MI 48109-0316 | en_US |
dc.contributor.affiliationum | Department of Internal Medicine (Division of Nuclear Medicine), The University of Michigan, Ann Arbor, MI 48109 | en_US |
dc.contributor.affiliationum | Departments of Physical Medicine and Rehabilitation, The University of Michigan, Ann Arbor, MI 48109 | en_US |
dc.contributor.affiliationum | Department of Neurology, The University of Michigan, Ann Arbor, MI 48109 | en_US |
dc.contributor.affiliationum | Department of Neurology, The University of Michigan, Ann Arbor, MI 48109 | en_US |
dc.contributor.affiliationum | Department of adiology, The University of Michigan, Ann Arbor, MI 48109 | en_US |
dc.identifier.pmid | 3265863 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/50327/1/410240310_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/ana.410240310 | en_US |
dc.identifier.source | Annals of Neurology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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