Recent progress toward understanding the molecular biology of von Recklinghausen neurofibromatosis
Gutmann, David H.; Collins, Francis S.
1992-05
Citation
Gutmann, David H.; Collins, Francis S. (1992)."Recent progress toward understanding the molecular biology of von Recklinghausen neurofibromatosis." Annals of Neurology 31(5): 555-561. <http://hdl.handle.net/2027.42/50350>
Abstract
The gene for von Recklinghausen neurofibromatosis (NF1) was recently identified by positional cloning and found to code for a large, ubiquitously expressed protein. This protein has both structural and functional similarity to a family of proteins with guanosine triphosphatase–activating properties, involved in the regulation of the protooncogene ras . One of the postulated functions of the NF1 gene product may relate to its ability to regulate ras -mediated cell proliferation. Selective pharmacotherapy directed at downregulating ras may be of benefit to patients with NF1.Publisher
Wiley Subscription Services, Inc., A Wiley Company
ISSN
0364-5134 1531-8249
Other DOIs
PMID
1596091
Types
Article
Metadata
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