Recent progress toward understanding the molecular biology of von Recklinghausen neurofibromatosis
dc.contributor.author | Gutmann, David H. | en_US |
dc.contributor.author | Collins, Francis S. | en_US |
dc.date.accessioned | 2007-04-06T18:54:35Z | |
dc.date.available | 2007-04-06T18:54:35Z | |
dc.date.issued | 1992-05 | en_US |
dc.identifier.citation | Gutmann, David H.; Collins, Francis S. (1992)."Recent progress toward understanding the molecular biology of von Recklinghausen neurofibromatosis." Annals of Neurology 31(5): 555-561. <http://hdl.handle.net/2027.42/50350> | en_US |
dc.identifier.issn | 0364-5134 | en_US |
dc.identifier.issn | 1531-8249 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/50350 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1596091&dopt=citation | en_US |
dc.description.abstract | The gene for von Recklinghausen neurofibromatosis (NF1) was recently identified by positional cloning and found to code for a large, ubiquitously expressed protein. This protein has both structural and functional similarity to a family of proteins with guanosine triphosphatase–activating properties, involved in the regulation of the protooncogene ras . One of the postulated functions of the NF1 gene product may relate to its ability to regulate ras -mediated cell proliferation. Selective pharmacotherapy directed at downregulating ras may be of benefit to patients with NF1. | en_US |
dc.format.extent | 805149 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology, and Psychiatry | en_US |
dc.title | Recent progress toward understanding the molecular biology of von Recklinghausen neurofibromatosis | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Departments of Neurology, Internal Medicine, and Human Genetics, Howard Hughes Medical Institute, The University of Michigan Medical School, Ann Arbor, MI ; 4570 MSRB 2, Howard Hughes Medical Institute, The University of Michigan, Ann Arbor, MI 48109-0650 | en_US |
dc.contributor.affiliationum | Departments of Neurology, Internal Medicine, and Human Genetics, Howard Hughes Medical Institute, The University of Michigan Medical School, Ann Arbor, MI | en_US |
dc.identifier.pmid | 1596091 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/50350/1/410310515_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/ana.410310515 | en_US |
dc.identifier.source | Annals of Neurology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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