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dc.contributor.authorGutmann, David H.en_US
dc.contributor.authorCollins, Francis S.en_US
dc.date.accessioned2007-04-06T18:54:35Z
dc.date.available2007-04-06T18:54:35Z
dc.date.issued1992-05en_US
dc.identifier.citationGutmann, David H.; Collins, Francis S. (1992)."Recent progress toward understanding the molecular biology of von Recklinghausen neurofibromatosis." Annals of Neurology 31(5): 555-561. <http://hdl.handle.net/2027.42/50350>en_US
dc.identifier.issn0364-5134en_US
dc.identifier.issn1531-8249en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/50350
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1596091&dopt=citationen_US
dc.description.abstractThe gene for von Recklinghausen neurofibromatosis (NF1) was recently identified by positional cloning and found to code for a large, ubiquitously expressed protein. This protein has both structural and functional similarity to a family of proteins with guanosine triphosphatase–activating properties, involved in the regulation of the protooncogene ras . One of the postulated functions of the NF1 gene product may relate to its ability to regulate ras -mediated cell proliferation. Selective pharmacotherapy directed at downregulating ras may be of benefit to patients with NF1.en_US
dc.format.extent805149 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherNeuroscience, Neurology, and Psychiatryen_US
dc.titleRecent progress toward understanding the molecular biology of von Recklinghausen neurofibromatosisen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPsychiatryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartments of Neurology, Internal Medicine, and Human Genetics, Howard Hughes Medical Institute, The University of Michigan Medical School, Ann Arbor, MI ; 4570 MSRB 2, Howard Hughes Medical Institute, The University of Michigan, Ann Arbor, MI 48109-0650en_US
dc.contributor.affiliationumDepartments of Neurology, Internal Medicine, and Human Genetics, Howard Hughes Medical Institute, The University of Michigan Medical School, Ann Arbor, MIen_US
dc.identifier.pmid1596091en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/50350/1/410310515_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/ana.410310515en_US
dc.identifier.sourceAnnals of Neurologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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