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Decreased striatal monoaminergic terminals in olivopontocerebellar atrophy and multiple system atrophy demonstrated with positron emission tomography

dc.contributor.authorGilman, Siden_US
dc.contributor.authorJunck, Larryen_US
dc.contributor.authorLohman, Mary E.en_US
dc.contributor.authorMartorello, Susanen_US
dc.contributor.authorFrey, Kirk A.en_US
dc.contributor.authorKoeppe, Robert A.en_US
dc.contributor.authorVander Borght, Thierry M.en_US
dc.contributor.authorLee, Lihsueh C.en_US
dc.contributor.authorJewett, Douglas M.en_US
dc.contributor.authorKilbourn, Michael R.en_US
dc.contributor.authorLittle, Roderick J. A.en_US
dc.date.accessioned2007-04-06T18:55:59Z
dc.date.available2007-04-06T18:55:59Z
dc.date.issued1996-12en_US
dc.identifier.citationGilman, Sid; Junck, Larry; Lohman, Mary; Martorello, Susan; Frey, Kirk A.; Koeppe, Robert A.; Vander Borght, Thierry M.; Lee, Lihsueh C.; Jewett, Douglas M.; Kilbourn, Michael R.; Little, Roderick (1996)."Decreased striatal monoaminergic terminals in olivopontocerebellar atrophy and multiple system atrophy demonstrated with positron emission tomography." Annals of Neurology 40(6): 885-892. <http://hdl.handle.net/2027.42/50363>en_US
dc.identifier.issn0364-5134en_US
dc.identifier.issn1531-8249en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/50363
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9007093&dopt=citationen_US
dc.description.abstractWe used [ 11 C]dihydrotetrabenazine, a new ligand for the type 2 vesicular monoamine transporter (VMAT2), with positron emission tomography to study striatal monoaminergic presynaptic terminals in 4 patients with multiple system atrophy, 8 with sporadic olivopontocerebellar atrophy, and 9 normal control subjects. Specific binding in the striatum was significantly reduced in the multiple system atrophy patients as compared with the normal control group, with average reductions of 61% in the caudate nucleus ( p = 0.002) and 58% in the putamen ( p = 0.009). Smaller reductions were found in the sporadic olivopontocerebellar atrophy group, averaging 26% in the caudate nucleus ( p = 0.05) and 24% in the putamen ( p = 0.11).Mean blood-to-brain [ 11 C]dihydrotetrabenazine transport (K 1 ) was significantly different between groups only in the cerebellum, with values for the sporadic olivopontocerebellar atrophy group diminished compared with the normal control group. Cerebellar K 1 was not significantly decreased in the multiple system atrophy group. The finding of reduced striatal WT2 in sporadic olivopontocerebellar atrophy patients suggests nigrostriatal pathology, indicating that some may later develop symptomatic extrapyramidal disease.en_US
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dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
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dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherNeuroscience, Neurology, and Psychiatryen_US
dc.titleDecreased striatal monoaminergic terminals in olivopontocerebellar atrophy and multiple system atrophy demonstrated with positron emission tomographyen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPsychiatryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan, Ann Arbor, MI ; Department of Neurology, University of Michigan Medical Center, 1550 E. Medical Center Drive, Ann Arbor, MI 48109-0316en_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan, Ann Arbor, MI ; Division of Nuclear Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDivision of Nuclear Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDivision of Nuclear Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDivision of Nuclear Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDivision of Nuclear Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDivision of Nuclear Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MIen_US
dc.contributor.affiliationumDeparmment of Biostatistics, University of Michigan, Ann Arbor, MIen_US
dc.identifier.pmid9007093en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/50363/1/410400610_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/ana.410400610en_US
dc.identifier.sourceAnnals of Neurologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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