Now showing items 1-10 of 41
A radiation hybrid map of the proximal short arm of the human X chromosome spanning incontinentia pigmenti 1 (IP1) translocation breakpoints
(Elsevier, 1992-11)
Radiation hybrid mapping was used in combination with physical mapping techniques to order and estimate distances between 14 loci in the proximal region of the short arm of the human X chromosome. A panel of radiation ...
Using sex-averaged genetic maps in multipoint linkage analysis when identity-by-descent status is incompletely known
(Wiley Subscription Services, Inc., A Wiley Company, 2006-07)
The ratio of male and female genetic map distances varies dramatically across the human genome. Despite these sex differences in genetic map distances, most multipoint linkage analyses use sex-averaged genetic maps. We ...
Resampling methods for variance estimation of singular value decomposition analyses from microarray experiments
(Springer-Verlag, 2002-08)
Microarray experiments offer the ability to generate gene expression measurements for thousands of genes simultaneously. Work has begun recently on attempting to reconstruct genetic networks based on analyses of microarray ...
Syndrome X: Is it for real?
(Wiley Subscription Services, Inc., A Wiley Company, 1998)
The term syndrome X has been applied to the association of hypertension, non-insulin-dependent diabetes mellitus (NIDDM), android obesity, insulin resistance, and dyslipidemia. In this paper, based on population samples ...
Localization of the Gene for ATP Citrate Lyase (ACLY) Distal to Gastrin (GAS) and Proximal to D17S856 on Chromosome 17q12-q21
(Elsevier, 1994-05-15)
The gene encoding ATP-citrate lyase, designated ACLY, was mapped to human chromosome 17q12-q21 by PCR on a panel of human/rodent somatic cell hybrids and localized to 17q21.1 by PCH on a panel of radiation hybrids. The ...
Univariate and bivariate analyses of cholesterol and triglyceride levels in pedigrees
(Wiley Subscription Services, Inc., A Wiley Company, 1986-03)
A multivariate normal model for pedigree analysis is applied to fasting total serum cholesterol and total serum triglyceride measurements on 771 individuals in 95 pedigrees from Rochester, MN. Univariate and bivariate ...
Haplotype association analysis for late onset diseases using nuclear family data
(Wiley Subscription Services, Inc., A Wiley Company, 2006-04)
In haplotype-based association studies for late onset diseases, one attractive design is to use available unaffected spouses as controls (Valle et al. [1998] Diab. Care 21:949–958). Given cases and spouses only, the standard ...
Covariate adjustment in the analysis of microarray data from clinical studies
(Springer-Verlag, 2005-01)
There is tremendous scientific interest in the analysis of gene expression data in clinical settings, such as oncology. In this paper, we describe the importance of adjusting for confounders and other prognostic factors ...
Genetic counseling for BRCA1 / 2 : A randomized controlled trial of two strategies to facilitate the education and counseling process This article contains supplementary material, which may be viewed at the American Journal of Medical Genetics website at http://www.interscience.wiley.com/jpages/1552–4825/suppmat/index.html .
(Wiley Subscription Services, Inc., A Wiley Company, 2005-04-01)
Due to the complexity of information surrounding BRCA1 / 2 counseling and testing and its time consuming nature, efforts to facilitate the genetic counseling and education process are needed. Using a 2 × 2 factorial ...
Multiple forms of genetic instability within a 2-Mb chromosomal segment of 3q26.3–q27 are associated with development of esophageal adenocarcinoma
(Wiley Subscription Services, Inc., A Wiley Company, 2006-04)
Gene amplification is one of the mechanisms to activate oncogenes in many cancers, including esophageal adenocarcinoma (EA). In the present study, we used two-dimensional restriction landmark genome scanning to clone a ...