Now showing items 11-20 of 54
Stress and female reproductive function: A study of daily variations in cortisol, gonadotrophins, and gonadal steroids in a rural Mayan population
(Wiley Subscription Services, Inc., A Wiley Company, 2004-09)
We report here on a longitudinal study of stress and women's reproduction in a small Kaqchikel Mayan community in rural Guatemala. Current understanding of the effects of stress on the reproductive axis in women is mostly ...
Generalizing the TITE-CRM to adapt for early- and late-onset toxicities
(John Wiley & Sons, Ltd., 2005)
Due to the staggered entry of subjects in phase I trials, some subjects will only be partially through the study when others are ready to be enrolled. Nonetheless, many phase I designs focus solely upon whether or not ...
Modelling tumour biology–progression relationships in screening trials
(John Wiley & Sons, Ltd., 2005)
There has been some recent work in the statistical literature for modelling the relationship between tumour biology properties and tumour progression in screening trials. While non-parametric methods have been proposed for ...
Randomization in clinical trials: Conclusions and recommendations
(Elsevier, 1988-12)
The statistical properties of simple (complete) randomization, permuted-block (or simply blocked) randomization, and the urn adaptive biased-coin randomization are summarized. These procedures are contrasted to covariate ...
PTSD and depression after the Madrid March 11 train bombings
(Wiley Subscription Services, Inc., A Wiley Company, 2006-02)
The March 11, 2004, train bombings in Madrid, Spain, caused the largest loss of life from a single terrorist attack in modern European history. We used a cross-sectional random digit dial survey of Madrid residents to ...
Bias reduction for risk ratio and vaccine effect estimators
(John Wiley & Sons, Ltd., 2001-06-15)
We examine the structural bias for established estimators of vaccine effects on susceptibility and for newer estimates of vaccine effects on infectiousness. We then propose and analyse new bias corrections for vaccine ...
Integrating education into primary care quality and cost improvement at an academic medical center
(Wiley Subscription Services, Inc., A Wiley Company, 2006)
Introduction: In 1996 the University of Michigan Health System created the Guidelines Utilization, Implementation, Development, and Evaluation Studies (GUIDES) unit to improve the quality and cost-effectiveness of primary ...