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G2019S mutation in the leucine-rich repeat kinase 2 gene is not associated with multiple system atrophy

Ozelius, Laurie J.; Foroud, Tatiana; May, Susanne; Senthil, Geetha; Sandroni, Paola; Low, Phillip A.; Reich, Stephen G.; Colcher, Amy; Stern, Matthew B.; Ondo, William G.; Jankovic, Joseph; Huang, Neng; Tanner, Caroline M.; Novak, Peter; Gilman, Sid; Marshall, Frederick J.; Wooten, G. Frederick; Chelimsky, Thomas C.; Shults, Clifford W.
2007-03-15

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Citation

Ozelius, Laurie J.; Foroud, Tatiana; May, Susanne; Senthil, Geetha; Sandroni, Paola; Low, Phillip A.; Reich, Stephen; Colcher, Amy; Stern, Matthew B.; Ondo, William G.; Jankovic, Joseph; Huang, Neng; Tanner, Caroline M.; Novak, Peter; Gilman, Sid; Marshall, Frederick J.; Wooten, G. Frederick; Chelimsky, Thomas C.; Shults, Clifford W. (2007)."G2019S mutation in the leucine-rich repeat kinase 2 gene is not associated with multiple system atrophy." Movement Disorders 22(4): 546-549. <http://hdl.handle.net/2027.42/56014>

Abstract

Multiple system atrophy (MSA) is characterized clinically by Parkinsonism, cerebellar dysfunction, and autonomic impairment. Multiple mutations in the LRRK2 gene are associated with parkinsonian disorders, and the most common one, the G2019S mutation, has been found in ∼1% of sporadic cases of Parkinsonism. In a well-characterized cohort of 136 subjects with probable MSA and 110 neurologically evaluated control subjects, none carried the G2019S mutation. We conclude that the G2019S mutation in the LRRK2 gene is unlikely to be associated with MSA. © 2007 Movement Disorder Society

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Wiley Subscription Services, Inc., A Wiley Company

ISSN

0885-3185
 
1531-8257
 

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PMID

17230458

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Article

Handle

https://hdl.handle.net/2027.42/56014

URI

http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17230458&dopt=citation

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