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G2019S mutation in the leucine-rich repeat kinase 2 gene is not associated with multiple system atrophy
dc.contributor.authorOzelius, Laurie J.en_US
dc.contributor.authorForoud, Tatianaen_US
dc.contributor.authorMay, Susanneen_US
dc.contributor.authorSenthil, Geethaen_US
dc.contributor.authorSandroni, Paolaen_US
dc.contributor.authorLow, Phillip A.en_US
dc.contributor.authorReich, Stephen G.en_US
dc.contributor.authorColcher, Amyen_US
dc.contributor.authorStern, Matthew B.en_US
dc.contributor.authorOndo, William G.en_US
dc.contributor.authorJankovic, Josephen_US
dc.contributor.authorHuang, Nengen_US
dc.contributor.authorTanner, Caroline M.en_US
dc.contributor.authorNovak, Peteren_US
dc.contributor.authorGilman, Siden_US
dc.contributor.authorMarshall, Frederick J.en_US
dc.contributor.authorWooten, G. Fredericken_US
dc.contributor.authorChelimsky, Thomas C.en_US
dc.contributor.authorShults, Clifford W.en_US
dc.date.accessioned2007-09-20T18:30:19Z
dc.date.available2008-04-03T18:53:56Zen_US
dc.date.issued2007-03-15en_US
dc.identifier.citationOzelius, Laurie J.; Foroud, Tatiana; May, Susanne; Senthil, Geetha; Sandroni, Paola; Low, Phillip A.; Reich, Stephen; Colcher, Amy; Stern, Matthew B.; Ondo, William G.; Jankovic, Joseph; Huang, Neng; Tanner, Caroline M.; Novak, Peter; Gilman, Sid; Marshall, Frederick J.; Wooten, G. Frederick; Chelimsky, Thomas C.; Shults, Clifford W. (2007)."G2019S mutation in the leucine-rich repeat kinase 2 gene is not associated with multiple system atrophy." Movement Disorders 22(4): 546-549. <http://hdl.handle.net/2027.42/56014>en_US
dc.identifier.issn0885-3185en_US
dc.identifier.issn1531-8257en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/56014
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17230458&dopt=citationen_US
dc.description.abstractMultiple system atrophy (MSA) is characterized clinically by Parkinsonism, cerebellar dysfunction, and autonomic impairment. Multiple mutations in the LRRK2 gene are associated with parkinsonian disorders, and the most common one, the G2019S mutation, has been found in ∼1% of sporadic cases of Parkinsonism. In a well-characterized cohort of 136 subjects with probable MSA and 110 neurologically evaluated control subjects, none carried the G2019S mutation. We conclude that the G2019S mutation in the LRRK2 gene is unlikely to be associated with MSA. © 2007 Movement Disorder Societyen_US
dc.format.extent58116 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherNeurologyen_US
dc.subject.otherNeuroscienceen_US
dc.titleG2019S mutation in the leucine-rich repeat kinase 2 gene is not associated with multiple system atrophyen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationotherDepartment of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York, USA ; Albert Einstein College of Medicine, Molecular Genetics, Ull 1211, 1300 Morris Park Ave.,Bronx, NY 10461en_US
dc.contributor.affiliationotherDepartment of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USAen_US
dc.contributor.affiliationotherDepartment of Neurosciences, University of California, La Jolla, San Diego, California, USA ; Department of Family and Preventive Medicine, University of California, La Jolla, San Diego, California, USAen_US
dc.contributor.affiliationotherDepartment of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York, USAen_US
dc.contributor.affiliationotherDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USAen_US
dc.contributor.affiliationotherDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USAen_US
dc.contributor.affiliationotherDepartment of Neurology, School of Medicine, University of Maryland, Baltimore, Maryland, USAen_US
dc.contributor.affiliationotherParkinson's Disease and Movement Disorders Center, Pennsylvania Hospital, Philadelphia, Pennsylvania, USAen_US
dc.contributor.affiliationotherParkinson's Disease and Movement Disorders Center, Pennsylvania Hospital, Philadelphia, Pennsylvania, USAen_US
dc.contributor.affiliationotherDepartment of Neurology, Baylor College of Medicine, Houston, Texas, USAen_US
dc.contributor.affiliationotherDepartment of Neurology, Baylor College of Medicine, Houston, Texas, USAen_US
dc.contributor.affiliationotherParkinson's Institute, Sunnyvale, California, USAen_US
dc.contributor.affiliationotherParkinson's Institute, Sunnyvale, California, USAen_US
dc.contributor.affiliationotherDepartment of Neurology, Boston University, Boston, Massachusetts, USAen_US
dc.contributor.affiliationotherDepartment of Neurology, University of Rochester, Rochester, New York, USAen_US
dc.contributor.affiliationotherDepartment of Neurology, University of Virginia Health System, Charlottesville, Virginia, USAen_US
dc.contributor.affiliationotherDepartment of Neurology, Case Western Reserve University, Cleveland, Ohio, USAen_US
dc.contributor.affiliationotherDepartment of Neurosciences, University of California, La Jolla, San Diego, California, USA ; Veterans Affairs San Diego Healthcare System, San Diego, California, USAen_US
dc.identifier.pmid17230458en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/56014/1/21343_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/mds.21343en_US
dc.identifier.sourceMovement Disordersen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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