Rapid aqueous photo-polymerization route to polymer and polymer-composite hydrogel 3D inverted colloidal crystal scaffolds
dc.contributor.author | Liu, Yuanfang | en_US |
dc.contributor.author | Wang, Shaopeng | en_US |
dc.contributor.author | Krouse, Justin | en_US |
dc.contributor.author | Kotov, Nicholas A. | en_US |
dc.contributor.author | Eghtedari, Mohammad | en_US |
dc.contributor.author | Vargas, Gracie | en_US |
dc.contributor.author | Motamedi, Massoud | en_US |
dc.date.accessioned | 2007-09-20T19:14:00Z | |
dc.date.available | 2008-11-05T15:05:43Z | en_US |
dc.date.issued | 2007-10 | en_US |
dc.identifier.citation | Liu, Yuanfang; Wang, Shaopeng; Krouse, Justin; Kotov, Nicholas A.; Eghtedari, Mohammad; Vargas, Gracie; Motamedi, Massoud (2007)."Rapid aqueous photo-polymerization route to polymer and polymer-composite hydrogel 3D inverted colloidal crystal scaffolds." Journal of Biomedical Materials Research Part A 83A(1): 1-9. <http://hdl.handle.net/2027.42/56168> | en_US |
dc.identifier.issn | 1549-3296 | en_US |
dc.identifier.issn | 1552-4965 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/56168 | |
dc.description.abstract | Successful regeneration of biological tissues in vitro requires the utilization of three-dimensional (3D) scaffolds that provide a near natural microenvironment for progenitor cells to grow, interact, replicate, and differentiate to form target tissues. In this work, a rapid aqueous photo-polymerization route was developed toward the fabrication of a variety of polymer hydrogel 3D inverted colloidal crystal (ICC) scaffolds having different physical and chemical properties. To demonstrate the versatility of this technique, a variety of polymer hydrogel ICC scaffolds were prepared, including (1) polyacrylamide (pAAM) scaffolds, (2) poly(2-hydroxyethyl methacrylate) (pHEMA) scaffolds, (3) poly(2-hydroxyethyl acrylate) (pHEA) scaffolds, and composite scaffolds including (4) pAAM-pHEMA scaffolds, (5) pHEMA-pMAETAC [poly(2-methacryloyloxy) trimethyl ammonium] scaffolds, and (6) pHEA-pMEATAC scaffolds. Templates for scaffolds incorporated both uniform sized (104 Μm diameter) and nonuniform sized (100 ± 20 Μm diameter) closely packed noncrosslinked poly(methyl methacrylate) beads. Human bone marrow stromal HS-5 cells were cultured on the six different types of scaffolds to demonstrate biocompatibility. Experimental results show that cells can remain viable in these scaffolds for at least 5 weeks. Of the six scaffolds, maximal cell adhesion and proliferation are obtained on the positively charged composite hydrogel pHEMA-pMEATAC and pHEA-pMAETAC scaffolds. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2007 | en_US |
dc.format.extent | 441027 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Chemistry | en_US |
dc.subject.other | Polymer and Materials Science | en_US |
dc.title | Rapid aqueous photo-polymerization route to polymer and polymer-composite hydrogel 3D inverted colloidal crystal scaffolds | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biomedical Engineering | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan 48109 ; Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109 ; Department of Materials Science, University of Michigan, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationother | ICx Nomadics, Inc., 1024S Innovation Way, Stillwater, Oklahama 74074 | en_US |
dc.contributor.affiliationother | ICx Nomadics, Inc., 1024S Innovation Way, Stillwater, Oklahama 74074 ; ICx Nomadics, Inc., 1024S Innovation Way, Stillwater, Oklahama 74074 | en_US |
dc.contributor.affiliationother | ICx Nomadics, Inc., 1024S Innovation Way, Stillwater, Oklahama 74074 | en_US |
dc.contributor.affiliationother | Center for Biomedical Engineering, University of Texas Medical Branch, Galveston, Texas 77555 | en_US |
dc.contributor.affiliationother | Center for Biomedical Engineering, University of Texas Medical Branch, Galveston, Texas 77555 ; Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555 | en_US |
dc.contributor.affiliationother | Center for Biomedical Engineering, University of Texas Medical Branch, Galveston, Texas 77555 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/56168/1/31199_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/jbm.a.31199 | en_US |
dc.identifier.source | Journal of Biomedical Materials Research Part A | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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