Now showing items 21-30 of 31
Similarity of the discriminative stimulus effects of ketamine, cyclazocine, and dextrorphan in the pigeon
(Springer-Verlag, 1981-05)
Separate groups of pigeons were trained to discriminate the IM injection of ketamine, cyclazocine, or dextrorphan from saline. Each of the training drugs and phencyclidine produced dose-related, drug-appropriate responding ...
Summary of a National Institute of Mental Health workshop: developing animal models of anxiety disorders
(Springer-Verlag, 2001-10)
Rationale: There exists a wide range of animal models and measures designed to assess anxiety or fearfulness. However, the relationship between these models and clinical anxiety symptoms and syndromes is unclear. The ...
A statistical approach for classifying change in cognitive function in individuals following pharmacologic challenge: an example with alprazolam
(Springer-Verlag, 2006-05)
The effects of any drug treatment on cognitive function are typically studied in groups of subjects. Observations made about the behavior of the drug, in the study sample, are then generalized to the population from which ...
Discriminative stimulus effects of etorphine in rhesus monkeys
(Springer-Verlag, 1981-03)
Two rhesus monkeys were trained to discriminate the IM injection of etorphine (0.001 mg/kg) from saline in a task in which 20 consecutive responses on one of two levers resulted in food delivery. In both monkeys, etorphine ...
Chronic administration of the delta opioid receptor agonist (+)BW373U86 and antidepressants on behavior in the forced swim test and BDNF mRNA expression in rats
(Springer-Verlag, 2005-11)
Selective delta opioid receptor agonists have been shown to produce antidepressant-like behavioral effects and increase brain-derived neurotrophic factor (BDNF) mRNA expression when given acutely, but the chronic effects ...
Sensitization to systemic amphetamine produces an enhanced locomotor response to a subsequent intra-accumbens amphetamine challenge in rats
(Springer-Verlag, 1991-05)
Repeated amphetamine (AMPH) administration into the nucleus accumbens does not enhance (sensitize) the locomotor activity produced by a subsequent systemic AMPH challenge. We report here, however, that pretreatment with ...
Antalarmin, a putative CRH-RI antagonist, has transient reinforcing effects in rhesus monkeys
(Springer-Verlag, 2002-11)
Abstract
Time course of transient behavioral depression and persistent behavioral sensitization in relation to regional brain monoamine concentrations during amphetamine withdrawal in rats
(Springer-Verlag, 1991-04)
This experiment was designed to characterize the withdrawal syndrome produced by discontinuation of treatment with escalating, non-neurotoxic doses of d -amphetamine (AMPH). AMPH withdrawal was associated with both transient ...
Response repetition in pigeons: pharmacological and behavioral specificity
(Springer-Verlag, 1986-12)
Using a reinforcement schedule that arranges random sequences of reinforcements over two response keys, low and high probabilities of repetition of non-reinforced responses were generated in two groups of pigeons ( n =3 ...
Benzodiazepine dependence studies in animals: An overview
(Wiley Subscription Services, Inc., A Wiley Company, 1982)
A selective review of benzodiazepine dependence studies in animals is presented, emphasizing areas of drug self-injection, drug discrimination, and physiological dependence. Benzodiazepines as a class, as well as long-acting ...