Now showing items 21-30 of 197
DENDRAL: A case study of the first expert system for scientific hypothesis formation
(Elsevier, 1993-06)
The DENDRAL Project was one of the first large-scale programs to embody the strategy of using detailed, task-specific knowledge about a problem domain as a source of heuristics, and to seek generality through automating ...
Systemic hormonal and physiological abnormalities in anxiety disorders
(Elsevier, 1988)
Among the studies of systemic hormonal and physiological abnormalities associated with anxiety disorders, the most consistent and extensive findings suggest (a) peripheral adrenergic hyperactivity (including increases in ...
Susceptibility to sensitization. II. The influence of gonadal hormones on enduring changes in brain monoamines and behavior produced by the repeated administration of -amphetamine or restraint stress
(Elsevier, 1988-09-01)
Repeated amphetamine use produces an enduring sensitization of brain dopamine (DA) systems and behavior. Repeated exposure to stress can also produce sensitization, and amphetamine and stress may be interchangeable in this ...
Dopamine depletion in neonatal rats: effects on behavior and striatal dopamine release assessed by intracerebral microdialysis during adulthood
(Elsevier, 1990-01-29)
Rats depleted of dopamine (DA) by intraventricular 6-hydroxydopamine (6-OHDA) in infancy show behavioral impairments as adults, but their basic sensory-motor functions and feeding abilities are intact; at least relative ...
The temporal structure of spike trains in the primate basal ganglia: afferent regulation of bursting demonstrated with precentral cerebral cortical ablation
(Elsevier, 1991-03-08)
We studied the temporal pattern of discharge of single units in the basal ganglia of awake primates sitting quietly. Bursting was studied with a procedure that identified individual bursts in a spike train, quantifying ...
The reinforcing property of ethanol in the rhesus monkey
(Springer-Verlag, 1978-01)
Rhesus monkeys received intravenous injections of ethanol during daily sessions contingent on their presses on an available lever. Under the standard conditions, when each response on the lever during a 3-h period each day ...
Genetic Algorithms and Machine Learning
(Kluwer Academic Publishers-Plenum Publishers; Kluwer Academic Publishers ; Springer Science+Business Media, 1988-10)
Effects of damage to superior colliculi and pre-tectum on movement discrimination in rhesus monkeys
(Springer-Verlag, 1984-08)
Eight rhesus monkeys (Macaca mulatta) were trained to detect an instantaneous lateral displacement of a small spot of light. The smallest movement for 79% correct performance was then determined. Severing the splenium of ...
Asymmetry in the effects of unilateral 6-OHDA lesions on eating and drinking evoked by hypothalamic stimulation
(Elsevier, 1985-05)
The present experiment investigated the effects of unilateral 6-hydroxydopamine lesions of the caudate nucleus and nucleus accumbens on eating and drinking evoked by electrical stimulation of the lateral hypothalamus (ESLH). ...
Localization and detection of visual stimuli following superior colliculus lesions in rhesus monkeys
(Elsevier, 1978-11-03)
Rhesus monkeys were trained to fixate a central stimulus and to detect and localize a 50 msec light flash presented 6-80[deg] on either side of the central stimulus. Following large lesions of the superior colliculus, they ...